THE ASSOCIATION OF SURVIVAL OF NEWBORNS WITH EXTREMELY LOW BODY WEIGHT WITH THE CARRIAGE OF GENES PREDISPOSITION TO THE INVERSE COURSE OF RESPIRATORY DISTRESS SYNDROME OF NEWBORNS

Abstract

The significance of genotype features in the outcomes of severe respiratory failure in newborns with extremely low body weight (ELBW) is not yet clear. The aim of the study was to assess the relationship of survival with the carrier of certain genes of predisposition to the reversible course of respiratory distress syndrome in newborns with ELBW. Methods. Design - controlled, prospective, non - randomized, single - center research. Inclusion criteria: newborns with ENMT less than 1000 g and gestational age of 28 or less weeks, ventilator for more than 3 days. Exclusion criteria: multiple malformations, gestational age less than 26 weeks, death in the first 48 hours of life. 88 patients were included in the development. Polymorphism of genes of surfactant B protein (SFTPB 1580 C>T), interleukin-1β (IL1B 3953 C>T), IL-1 receptor antagonist (VNTR polymorphism of intron 2 IL-1RN), interleukin-10 (IL10 627 C>A), tumor necrosis factor (TNF-α 308 G>A), prothrombin gene (F2-20210 G>A), coagulation factor 5 (Leiden) gene (F5-1691 G>A), proconvertin gene (F7-10976 G>A), Hageman factor gene (F13), fibrinogen B gene (FGB 455), platelet integrin - alpha gene (ITGA2 807 C>T), platelet fibrinogen subunit betta gene (ITGB3-1565 T>C), a type 1 plasminogen activation inhibitor gene (PAI-1 675). Results. The data obtained indicate that there is no relationship between the distribution of alleles and genotypes of the studied genes and the survival of patients. Conclusion. The carriage of the studied genes of predisposition to the development of respiratory distress syndrome of newborns, infectious complications and thrombophilia in newborns with ELBW is not associated with their survival in the neonatal period.