COMPREHENSIVE APPROACH TO ACNE TREATMENT IN ADOLESCENT GIRLS

Abstract

Currently, the drugs of the first choice for acne treatment are systemic retinoids. They are prescribed to girls teenagers in combination with combined oral contraceptives (COC), because retinoids can cause a teratogenic effect. This group of drugs has a pronounced hepatotoxic effect, which should be considered when using them in standard acne treatment regimens. Therefore, to prevent the development of such complications, it is necessary to search, develop and implement safe combinations, including those with a hepatoprotective effect. Purpose of the study: to study the effect of Ursofalk on the tolerability and effectiveness of systemic therapy with isotretinoin in adolescent patients with severe acne taking COC. Materials and methods: 60 girls aged 19.4 ± 5.3 years with severe acne, confirmed by instrumental and clinical laboratory methods of examination, were examined. All patients were randomized into two groups. In each group, a general clinical examination was carried out, a clinical assessment of the effectiveness of acne therapy was carried out on the basis of the severity of erythema and infiltration according to a 4-point system, the index of the clinical course. Results: in both groups, there was a significant regression of erythema and infiltration with a significant decrease in the number of inflammatory elements. The effectiveness of systemic retinoid therapy against acne was high in both groups, however, the tolerability of long term therapy in the general group was higher due to the hepatoprotective effect of Ursofalk. In addition, the absence of violations of both the lipid spectrum of blood and carbohydrate metabolism in the general group of the study was noted. Therefore, to prevent the development of such complications, it is necessary to search, develop and introduce into practice safe combinations, including those with drugs with hepatoprotective action.