Pharm-EEG in Patients with Long Unconscious Status

  • M.V. Aleksandrov Federal Almazov Medical Research Centre 2 Akkuratova str., Saint-Petersburg, Russia, 197341
  • S.A. Vasiliev Saint Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine 3, Budapeshtskaya str., St. Petersburg, 192242 Russia
  • A.V. Arutyunyan Saint Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine 3, Budapeshtskaya str., St. Petersburg, 192242 Russia
  • S.A. Lytaev Saint-Petersburg State Pediatric Medical University Litovskaya str., 2. Saint-Petersburg, Russia, 194100
Keywords: acute poisoning, neurotoxicity, acute cerebral insufficiency, EEG, bioelectric activity

Abstract

The main syndrome of severe poisoning is coma. An option of coma outcome is a vegetative state. EEG reactivity due to intravenous benzodiazepines estimates the prognosis for such patients. However, a positive benzodiazepines test has the predictability of about 50-60%. The aim of the work is to assess the role of interaction between gamma amino butyric acid (GABA) and cholinergic systems of the brain. The consequent injections of benzodiazepine and atropine lead to a 20% increase in predictability. The results obtained confirm the following hypothesis. Abnormality of GABA-cholinergic interaction is one of the mechanisms of forming a stable pathological system resulting in the pathogenesis of the vegetative state

Published
2019-08-09
How to Cite
Aleksandrov, M., Vasiliev, S., Arutyunyan, A., & Lytaev , S. (2019). Pharm-EEG in Patients with Long Unconscious Status. Russian Biomedical Research, 2(1), 8-12. Retrieved from https://ojs3.gpmu.org/index.php/biomedical-research/article/view/400
Issue
Vol 2 No 1 (2017)
Section
Статьи