CHRONOMEDICAL APPROUCH TO METABOLIC SYNDROME

Abstract

The goal of the study was to assess the role of two behavioral acts (conscious choice of timely moment of maximum volume of food intake and conscious attitude to the timeliness of bowel) in the genesis of one of the major risk factors of metabolic syndrome — obesity. Method of chronoenterographia and using questionnaires to study the main aspects of quality of life (health, physical activity, mood) examined 40 patients with cardiac profile age from 24 to 76 years (25 women and 15 men) who have identified the risk of obesity. Surveyed 61 doctors aged 25 to 69 years by special questionnaires with regard to quality of diet, physical activity, sleep-wakefulness and quality of life. It is established that the violation of the circadian rhythm of defecation in the form of braenteria can be diagnosed in almost every second surveyed who consider themselves healthy and almost every second patient with metabolic syndrome with obesity and cardiovascular disease. The key pathogenetic mechanism of braenteria is the lack of morning acrophase defecation. Installed significantly higher risk of obesity in individuals with braenteria compared to those with euenteria. In individuals with obesity revealed a shift of acrophase of the meal maximum it was in the evening period of the day. Thus, the risk of obesity in individuals with metabolic syndrome depends on disturbance of circadian rhythm evacuation of bowel function and the absence of morning rhythm acrophase of defecation, as well as violations of circadian biorhythm nutrition in the form of receiving the maximum amount of food in the evening hours.