ATOPIC DERMATITIS AND DISEASES OF THE GASTROINTESTINAL TRACT

Abstract

Comorbidity is one of the features of chronic diseases of the upper gastrointestinal tract (GIT) in children. [1, 2, 3]. The relationship between allergic diseases and digestive organs is of particular interest [4, 5, 6]. Assumably, it’s possible to have direct allergic damage to the mucous membranes of the esophagus, stomach and intestines by various allergens; damage of other organs with increased permeability of the gastrointestinal epithelial barrier for allergens, and the simultaneous development of local inflammation of the gastrointestinal mucous membranes; and secondary damage to the digestive organs in primary allergic damage to other organs and systems [6]. Since the mucous membrane of the esophagus is the first among other digestive organs to be in contact with other allergens entering the gastrointestinal tract, the relationship between allergic reactions and pathologies of the esophagus is of particular interest among the researchers today [7, 8, 9]. Eosinophilic esophagitis is currently considered to be a manifestation of a systemic allergic reaction, along with other atopic diseases. About 35-45% of patients with eosinophilic esophagitis have food allergies, asthma, or atopic dermatitis (ATD) in their family history; an elimination diet is used for treatment [10, 11]. Despite the fact that esophageal diseases in patients with atopic disease are of current interest among pediatricians, allergists, pediatric gastroenterologists and endoscopists, the prevalence, etiology, pathogenesis and diagnosis of comorbid allergic pathology and esophageal diseases in childhood have not been fully studied yet.