Hereditary connective tissue disorders as a constitutional basis for the deficiency of body weight and bone mineral density

Abstract

Low body weight is one of the most common reasons for the postponement of conscripts from military service. At low body weight, bone formation is disrupted, as a result osteopenia is formed. The association of low body weight and bone mineral density (BMD) with marfanoid habitus (MH) has not studied. Materials and methods. Was surveyed 327 young men between the ages of 18 and 25 - 247 students and 80 young men who were examined at the City Mariinsky Hospital (St. Petersburg) with a low body weight. All the subjects were examined anthropometric and phenotypic examinations. 80 young men was executed X-ray osteodensitometry of the lumbar spine (LI-LIV). Results. Low body weight detected in 5.6% of almost healthy men. For men with low body weight characterized by a higher frequency of detection of bone and skin signs of dysembryogenesis: deformities of the chest, high palate, arachnodactylia, thin and velvety skin and atrophic striae. Among young men with MH, malnutrition detected in 45% of cases. For males with MH, the values of BMD were significantly lower compared to the control group (-1.23±0.73 vs 0.34±0.80, p=0.00001). The lower BMD of less than -1.5 STD detected in a third of men with MH and did not meet in control. Conclusion. Low body weight and osteopenia at a young age are associated with bone signs of dysembryogenesis - marfanoid habitus.