BOWEL MOTILITY FUNCTION IN PATIENTS WITH METABOLIC SYNDROME

Abstract

Metabolic syndrome (MtS) is one of the most important predictors of a number of diseases, including digestive tract pathology. The liver, pancreas, and intestines are involved in the pathologic process at first. At this stage of MtS investigation the amount of knowledge about the relationship between pathogenetic mechanisms is very limited and requires the detailed study. Aim: to assess the state of intestinal motility function and the dynamics of the development of motility evacuation intestinal dysfunction with impaired bowel movement in patients with MtS. Materials and methods: 377 patients were examined, age was 48,7±11,6 years. Diagnostics of MtS was carried out on the basis of criteria formulated by experts of the Russian Scientific Society of Cardiology (VNOK) and the International Diabetes Federation (IDF). The study was performed in two stages: selection of patients meeting the inclusion criteria, their comprehensive examination and questionnaire according to a special validated questionnaire and screening tests to assess intestinal motility function; the second is a prospective observation of selected patients for two years. Results and Discussion: for patients with severe obesity and an early manifestation of MtS, the presences of non alcoholic pancreatic fatty disease and motor bowel disorder with a violation of the bowel movement as a diarrhea are characteristic. Over time, all respondents observed the development and progression of the pathology of motility evacuation function with a change in the act of defecation from constipation to diarrhea. Conclusions: the course of MtS is of a staged nature with a gradual dynamics of the development of motility dysfunction of the intestine and the involvement of all digestive organs in the pathological process.