Virus Epstein-Barr at a gastrointestinal diseases

Abstract

Currently, there remains a high interest in diseases caused by herpes viruses, among which the Epstein-Barr virus (VEB) takes the leading place. Almost 90 % of the world’s population over the age of 40 is infected with VEB. In patients of the first two years, the proportion of asymptomatic carriage reaches 90 %, and at the age of 2-10 years - 30-50 %. It has been shown that EBV plays a role in the occurrence of gastric adenocarcinoma, chronic esophagitis, gastritis and gastroduodenitis, bowel disease. VEB inhibits apoptosis, affecting a number of regulatory intracellular proteins and receptors, modifies the expression of long non coding RNAs (lncRNAs), which play a crucial role in the regulation of various cellular processes. In recent years, co infection of H. pylori and VEB has been actively studied, mutually aggravating the pathological effect of each other. It is necessary to further study the mechanisms of the pathological action of VEB on the gastrointestinal mucosa in order to search for targeted therapy of related diseases.