INTERLEUKIN-10. BIOLOGICAL ROLE AND CLINICAL SIGNIFICANCE
Abstract
Purpose: based on the analysis of modern scientific literature, using electronic databases - PubMed, CellPress, Uptodate, E-library, Google Scholar, to describe the biological and clinical significance of the anti inflammatory cytokine interleukin-10 (IL-10). The review presents data from experimental, clinical and laboratory studies of IL-10 in oncological, autoimmune, allergic, infectious and other diseases, which allow us to conclude about its role in the development and outcome of the pathological process depending on the polymorphism of the IL-10 gene, as well as its paradoxical effect on certain diseases. IL-10 serves as an important regulator of the immune response, suppressing the activity of macrophages and Th1 cells and ensuring the implementation of certain biological effects of Th2. Anti inflammatory cytokine IL-10 has the ability to suppress immune inflammation and is an important regulator of cytokinogenesis, largely determining the direction of immune responses.
