Bronchial asthma and diseases of the gastrointestinal tract in children. The mechanisms of interconnection

Abstract

The high prevalence of asthma in the past three to four decades has become a serious public health problem due to the frequent disability and mortality of patients. Bronchial asthma refers to heterogeneous diseases with multifactorial conditioning and the interaction of numerous somatic and mental components. In recent years, much attention has been paid to the importance of dysbiotic changes in the intestinal mucosa in children with bronchial asthma.The leading role of microbiota in the emergence and support of atopy in children is assumed. Other mechanisms of the relationship of gastrointestinal diseases and bronchial asthma are undifferentiated connective tissue dysplasia, obesity, eosinophilic and neuropeptide inflammation. The establishment of the BA phenotype in relation to gastrointestinal diseases is necessary for the appointment of targeted individualized treatment for each patient.