Cardiac arrhythmias in patients with cancer

Abstract

Cancer is one of the leading causes of death and disability in the population. The progress of drug and radiation therapy has significantly increased the life expectancy of cancer patients, thanks to advanced diagnostics and innovative treatment regimens, but at the same time the number of patients with complications from the cardiovascular system has increased. Many works have been devoted to the problem of cardiotoxicity, but nevertheless, there are still many important questions regarding the tactics of examination and treatment of such patients. The article deals with the urgent problem of cardiotoxicity of chemotherapy drugs, radiation therapy, considered the arrhythmogenic effects of the most commonly used anticancer drugs: anthracycline antibiotics. Arrhythmias and conduction disturbances, influence on electrocardiographic parameters, action potential of cardiomyocytes, cardiac ion currents caused by chemotherapy, radiation therapy can lead to dose reduction or cancellation of anticancer drugs and require careful monitoring, a joint approach of doctors of several specialties to the management of these patients.