COMORBIDITY OF PARODONTAL PATHOLOGY AND ISCHEMIC HEART DISEASE
Abstract
This article discusses the relationship between coronary heart disease and periodontal disease. The concomitant course of comorbid cardiovascular and dental pathology requires joint efforts from cardiologists and dentists to modify common risk factors. It has been established that these diseases are of an inflammatory nature, the pathogenetic link that enhances the relationship between the severity of periodontal inflammatory changes and the development of atherosclerosis with cardiovascular diseases is a systemic inflammatory response. When planning therapeutic and preventive measures in patients with diseases of the cardiovascular system, the condition of the periodontium should be taken into account. An urgent problem of modern medicine is the development of interdisciplinary interaction between internists and dentists, aimed at developing unified approaches to the treatment of patients with somatic and dental diseases.
References
Елисеева Е.Ф. Сочетанное поражение десны пародонта и сердечно-сосудистой системы, клинико-морфологическое и микробиологическое исследование. Автореф. дис. … канд. мед. наук. СПб.; 2014.
Lockhart P.B., Bolger A.F., Papapanou P.N. et al. Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association: A Scientific Statement From the American Heart Association. Circulation. 2012; 125: 2520–44.
Fiorillo L., Cervino G., Laino L. et al. Porphyromonas gingivalis, periodontal and systemic implications: systematic Review. Dent J. 2019; 7(4): 114. DOI:10.3390/dj7040114.
Van der Bijl P. jr, Van der Bijl P. Infective endocarditis andantibiotic prophylaxis — an update for South African dental practitioners. SAD J. 2014; 69: 116–9.
Трухан Д.И., Трухан Л.Ю. Некоторые аспекты коморбидности пародонтита и сердечно-сосудистых заболеваний. Медицинский совет. 2015; 17: 12–6.
Zhang D.H., Yuan Q.N., Zabala P.M. et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J. 2014; 60(4): 455–62. DOI: 10.1111/adj.12253.
Golpasand Hagh L., Zakavi F., Hajizadeh F., Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J. 2014; 16(12): e6577.
Sandi R.M., Pol K.G., Basavaraj P. et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein(HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res. 2014; 8(1): 214–6. DOI: 10.7860/ JCDR/2014/6686.3927. Epub 2014 Jan 12.
Caula A.L., Lira-Junior R., Tinoco E.M., Fischer R.G. The effect of periodontal therapy on cardiovascularrisk markers: a 6-month randomized clinical trial. J Clin Periodontol. 2014; 41(9): 875–82.
Cullinan M.P., Palmer J.E., Faddy M.J. et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): A Randomized Controlled Trial. J Periodontol. 2015; 86(7): 847–55.
Friedewald V.E., Kornman K.S., Beck J.D. et al. The American Journal of Cardiology and Journal of Periodontology editors’ consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol. 2009; 80: 1021–32.
Franek E., Januszkiewicz-Caulier J., Błach A. et al. Intima-media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol. 2012; 70(1): 7–13.
Lira-Junior R., Figueredo C.M., Bouskela E., Fischer R.G. Severe chronic periodontitis is associated with endothelial and microvascular dysfunctions: a pilot study. J. Periodontol. 2014; 85(12): 1648–57. DOI:10.1902/jop.2014.140189.
Marfil-Alvarez R., Mesa F., Arrebola-Moreno A. et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res. 2014; 93(10): 993–8.
Joshi C., Bapat R., Anderson W. et al. Detection of periodontal microorganisms in coronary atheromatous plaque specimens of myocardial infarction patients: a systematic review and meta-analysis. Trends Cardiovasc Med. 2021; 31: 69–82.
Царев В.Н., Николаева В.Н., Витович М.В. и др. Биопленкообразующие бактерии в атеросклеротических бляшках у пациентов с сердечно-сосудистыми заболеваниями и хроническим пародонтитом. Клиническая стоматология. 2020; 2: 40–5.
Vidal F., Cordovil I., Figueredo C.M., Fischer R.G. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin. Periodontol. 2013; 40(7): 681–7.
Грудянов А.И., Ткачёва О.Н., Авраамова Т.В., Хватова Н.Т. Оценка взаимосвязи пародонтита и сердечно-сосудистых заболеваний. Фарматека. 2015; 13: 29–31.
De Nardin E. The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Ann. Periodontol. 20016: 30–40.
Ramirez J.H., Parra B., Gutierrez S. et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J. 2014; 59(1): 29–36.
Горбачева И.А., Сычева Ю.А. Орехова Л.Ю. Использование метаболической терапии в лечении больных с сочетанной патологией внутренних органов и пародонта. Ученые записки. 2017; 24(4): 55–63.
Reichert S., Schlumberger W., Dahnrich C. et al. Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of Rheumatoid arthritis: a case control study. J Transl Med. 2015; 13: 283.
Park S.Y., Kim S.H., Kang S.H. et al. Improved hygiene attenuates cardiovascular risk oral health disease: population-based from Korea. Eur Heart J. 2019; 40: 113845. DOI:10.1093/eurheartj/ehy83.
D’Aiuto F., Gkranias N., Bhowruth D. et al. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol. 2018; 6: 954–65.
Lopez N.J., Quintero A., Casanova P.A. et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. J Periodontol. 2012; 83(3): 267–78.
Roca-Millan E., González-Navarro B., Sabater-Recolons M.M. et al. Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal 2018; 23: e681–90. DOI:10.4317/medoral.22725/
Lavigne S.E., Forrest J.L. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal disease and cardiovascular diseases: position paper from the Canadian Dental Hygienists Association. Can J Dent Hyg. 2020; 54: 32–41.
Горбачева И.А., Сычева Ю.А. Патология пародонта и артериальная гипертензия. University Therapeutic Journal. 2023; 5(3): 59–68.
Estanislau I.M., Terceiro I.R., Lisboa M.R. et al. Pleiotropic effects of statins on the treatment of chronic periodontitis —a systematic review. Br J Clin Pharmacol. 2015; 79(6): 877–85. DOI: 10.1111/bcp.12 564.
Subramanian S., Emami H., Vucic E. et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. JACC. 2013; 62(25): 2382–91.
