FEATURES OF HEMODYNAMICS AND MYOCARDIAL REMODELING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITHOUT CONCOMITANT CARDIOVASCULAR PATHOLOGY IN COMPARISON WITH THE CLINICAL PHENOTYPE OF THE DISEASE
Abstract
The Russian Federation is one of the countries with a high prevalence of chronic obstructive pulmonary disease. The leading reason that efforts to prevent and treat COPD do not reduce the prevalence and mortality from this pathology should be considered the late detection of cardiovascular complications, due to the asymptomatic course in the early stages. The aim of the study was to analyze the features of hemodynamics and remodeling of the myocardium in patients with COPD without concomitant cardiovascular pathology in comparison with the clinical phenotype of the disease. The study included 155 patients with different clinical phenotypes of COPD who are registered for the main disease. The median age of patients with COPD was 61.0 [58.9; 62.4; CI — 95 %] years. There were 110 (73.3 %) men and 40 (26.7 %) women in the observation group. The index of the bundle of years was 30.0 [19.9; 25.1 CI — 95 %] years. To achieve this goal, all patients underwent echocardiographic examination by parasternal access with an assessment of hemodynamics and the main structural parameters of the myocardium. A comparative analysis of the study results revealed more pronounced early changes in intracardiac and pulmonary hemodynamics in patients with the clinical phenotype of COPD + emphysema with exacerbations. The absence of cardiovascular pathology and risk factors for its development in COPD patients does not exclude the presence of significant remodeling of the heart and hemodynamic disorders, and therefore it is necessary to conduct a comprehensive examination of the cardiovascular system to identify early subclinical disorders in patients with COPD with mild to moderate severity of bronchial obstruction.
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