DERMATOLOGICAL MANIFESTATIONS OF INFLAMMATORY BOWEL DISEASES. CLINICAL CASE WITH GANGRENOUS PYODERMA
Abstract
Inflammatory bowel disease is a chronic, relapsing, disabling disease characterized by damage to the digestive system and often manifested by extraintestinal complications. In second place among extraintestinal manifestations after the pathology of the musculoskeletal system is skin lesions. Dermatological manifestations include a diverse range of diseases, accompanied by asymptomatic course or severe clinical manifestations, requiring the provision of specialized medical care. The most common skin manifestations are erythema nodosum, pyoderma gangrenosum, and aphthous stomatitis. This article presents a clinical case of the development of pyoderma gangrenosum in a patient with the onset of ulcerative colitis with a detailed description of the evolution of morphological elements on the skin, the dynamics of the disease and treatment.
References
Aberumand B., Howard J., Howard J. Metastatic Crohn’s Disease: An Approach to an Uncommon but Important Cutaneous Disorder. Biomed Res Int. 2017; 2017: 8192150. DOI: 10.1155/2017/8192150. Epub 2017 Jan 3. PMID: 28127561; PMCID: PMC5239966.
Alavi A., French L.E., Davis M.D. et al. Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment. Am J Clin Dermatol. 2017; 18(3): 355–72. DOI: 10.1007/s40257-017-0251-7
Alshahrani K.S., Almohaya A.M., Hussein R.S., Ali R.H. Enthesitis in Bowel-Associated Dermatosis-Arthritis Syndrome in an Ulcerative Colitis Patient. Case Rep Rheumatol. 2022; 2022: 4556250. DOI: 10.1155/2022/4556250. PMID: 35462852; PMCID: PMC9019431.
Antonelli E., Bassotti G., Tramontana M. et al. Dermatological Manifestations in Inflammatory Bowel Diseases. J Clin Med. 2021; 10(2): 364. DOI: 10.3390/jcm10020364. PMID: 33477990; PMCID: PMC7835974.
Aromolo I.F., Simeoli D., Maronese C.A. et al. The Bowel-Associated Arthritis-Dermatosis Syndrome (BADAS): A Systematic Review. Metabolites. 2023; 13(7): 790. DOI: 10.3390/metabo13070790. PMID: 37512497; PMCID: PMC10386568.
Beraldo R.F., Marcondes M.B., Baima J.P. et al. Hidradenitis Suppurativa as a Paradoxical Side Effect to the Use of Adalimumab in Patients with Crohn’s Disease? Clin Exp Gastroenterol. 2020; 13: 293–8. DOI: 10.2147/CEG.S263685. PMID: 32943900; PMCID: PMC7473976.
Bollegala N., Khan R., Scaffidi M.A et al. Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature. Can J Gastroenterol Hepatol. 2017; 2017: 5124354. DOI: 10.1155/2017/5124354. Epub 2017 Feb 6. PMID: 28265555; PMCID: PMC5317120.
Catalán-Serra I., Martín-Moraleda L., Navarro-López L. et al. Crohn’s disease and Sweet’s syndrome: an uncommon association. Rev Esp Enferm Dig. 2010; 102(5): 331–7. DOI: 10.4321/s1130-01082010000500009. PMID: 20524763.
Fillman H., Riquelme P., Sullivan P.D., Mansoor A.M. Aseptic abscess syndrome. BMJ Case Rep. 2020; 13(10): e236437. DOI: 10.1136/bcr-2020-236437. PMID: 33122231; PMCID: PMC7597475.
George C., Deroide F., Rustin M. Pyoderma gangrenosum — a guide to diagnosis and management. Clin Med (Lond). 2019; 19(3): 224–8. DOI: 10.7861/clinmedicine.19-3-224. PMID: 31092515; PMCID: PMC6542232.
Hafsi W., Badri T. Erythema Nodosum. 2022 Nov 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. PMID: 29262192
Heard M., Zhang M., Jorizzo J.L. A case of bowel-associated dermatosis-arthritis syndrome treated with ustekinumab: The importance of targeting underlying gastrointestinal disease. JAAD Case Rep. 2020; 6(6): 506–8. DOI: 10.1016/j.jdcr.2020.04.001. PMID: 32490110; PMCID: PMC7256244.
Heath M.S., Ortega-Loayza A.G. Insights Into the Pathogenesis of Sweet’s Syndrome. Front Immunol. 2019; 10: 414. DOI: 10.3389/fimmu.2019.00414. PMID: 30930894; PMCID: PMC6424218.
Ickrath F., Stoevesandt J., Schulmeyer L. et al. Metastatic Crohn’s disease: an underestimated entity. J Dtsch Dermatol Ges. 2021; 19(7): 973–82. DOI: 10.1111/ddg.14447. Epub 2021 May 7. PMID: 33960613
Jockenhöfer F., Wollina U., Salva K.A. et al. The
PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum. Br J Dermatol. 2019; 180(3): 615–20. DOI: 10.1111/bjd.16401
Luporini R.L., Silva PCBDAC and Regueiro M. Hidradenitis suppurativa: Coexistence or dermatological extraintestinal manifestation of Crohn’s disease? Front. Med. 2023; 10: 1151370. DOI: 10.3389/fmed.2023.1151370
Maverakis E., Ma C., Shinkai K. et al. Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. JAMA Dermatol. 2018; 154(4): 461–6. DOI: 10.1001/jamadermatol.2017.5980
Maverakis E., Marzano A.V., Le S.T. et al. Pyoderma gangrenosum. Nat Rev Dis Primers. 2020; 6(1): 81. DOI: 10.1038/s41572-020-0213-x
Mimoz O., Benoist J.F., Edouard A.R. et al. Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med. 1998; 24(2): 185–8. DOI: 10.1007/s001340050543. PMID: 9539079
Owczarczyk-Saczonek A., Kasprowicz-Furmańczyk M., Kuna J. et al. Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient. Medicina (Kaunas). 2022; 58(10): 1354. DOI: 10.3390/medicina58101354. PMID: 36295515; PMCID: PMC9609381.
Pérez-Garza D.M., Chavez-Alvarez S., Ocampo-Candiani J., Gomez-Flores M. Erythema Nodosum: A Practical Approach and Diagnostic Algorithm. Am J Clin Dermatol. 2021; 22(3): 367–78. DOI: 10.1007/s40257-021-00592-w. Epub 2021 Mar 8. PMID: 33683567; PMCID: PMC7938036.
Requena L., Sánchez Yus. E. Erythema nodosum. Semin Cutan Med Surg. 2007; 26(2): 114–25. DOI: 10.1016/j.sder.2007.02.009. PMID: 17544964.
Rocha T.B., Garate ALSV., Beraldo R.F. et al. Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn’s Disease. Case Rep Gastroenterol. 2021; 15(3): 825–31. DOI: 10.1159/000519003. PMID: 34720830; PMCID: PMC8543354.
Russo I., Ferrazzi A., Zanetti I., Alaibac M. Epidermolysis bullosa acquisita in a 17-year-old boy with Crohn’s disease. BMJ Case Rep. 2015; 2015: bcr2015210210. DOI: 10.1136/bcr-2015-210210. PMID: 26163555; PMCID: PMC4499763
Salgado-Peralvo A.O., Montero-Alonso M., Kewalramani N. et al. Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2022; 27(6): e588-e599. DOI: 10.4317/medoral.25528. PMID: 36173720; PMCID: PMC9648636.
Samsudin I., Vasikaran S.D. Clinical Utility and Measurement of Procalcitonin. Clin Biochem Rev. 2017; 38(2): 59–68. PMID: 29332972; PMCID: PMC5759088.
Sbeit W., Kadah A., Mahamid M. et al. Oral manifestations of inflammatory bowel disease: the neglected piece of the puzzle. Eur J Gastroenterol Hepatol. 2020; 32(11): 1422–31. DOI: 10.1097/MEG.0000000000001918. PMID: 32925508
Sleiman J., Hitawala A.A., Cohen B. et al. Systematic Review: Sweet Syndrome Associated with Inflammatory Bowel Disease. J Crohns Colitis. 2021; 15(11): 1864–76. DOI: 10.1093/ecco-jcc/jjab079. PMID: 33891004; PMCID: PMC8675328.
Streight K.L., Braun T.L., Lowe N., Kim S.J. A Rare Clinical Presentation of Metastatic Crohn’s Disease. Cureus. 2020; 12(5): e8285. DOI: 10.7759/cureus.8285. PMID: 32467818; PMCID: PMC7250390.
Sy A., Khalidi N., Dehghan N. et al. Vasculitis Clinical Research Consortium (VCRC); Canadian Vasculitis Network (CanVasc). Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature. Semin Arthritis Rheum. 2016; 45(4): 475–82. DOI: 10.1016/j.semarthrit.2015.07.006. Epub 2015 Jul 26. PMID: 26315859; PMCID: PMC4982464.
Tešanović Perković D., Bukvić Mokos Z., Marinović B. Epidermolysis Bullosa Acquisita-Current and Emerging Treatments. J Clin Med. 2023; 12(3): 1139. DOI: 10.3390/jcm12031139. PMID: 36769788; PMCID: PMC9917799.
Trefond L., Frances C., Costedoat-Chalumeau N. et al. On Behalf Of The French Study Group On Aseptic Abscesses. Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series. J Clin Med. 2022; 11(13): 3669. DOI: 10.3390/jcm11133669. PMID: 35806955; PMCID: PMC9267245
Veloso F.T. Extraintestinal manifestations of inflammatory bowel disease: do they influence treatment and outcome? World J Gastroenterol. 2011; 17(22): 2702–7. DOI: 10.3748/wjg.v17.i22.2702. PMID: 21734777; PMCID: PMC3122258.
Villarreal-Villarreal C.D., Ocampo-Candiani J., Villarreal-Martínez A. Sweet Syndrome: A Review and Update. Actas Dermosifiliogr. 2016; 107(5): 369–78. English, Spanish. DOI: 10.1016/j.ad.2015.12.001. Epub 2016 Jan 27. PMID: 26826881.
Who first described Erythema Nodosum? Доступен по: http://www.biomedcentral.com/1471–2393/10/47/. (дата обращения 17.07.2023).
Zhang M., Chen Q.D., Xu H.X. et al. Association of hidradenitis suppurativa with Crohn’s disease. World J Clin Cases. 2021; 9(15): 3506–16. DOI: 10.12998/wjcc.v9.i15.3506. PMID: 34046451; PMCID: PMC8130070.