SHORT BOWEL SYNDROME IN ADULTS: FEATURES OF MANIFESTATION AND POSSIBILITIES OF DIFFERENTIATED THERAPY
Abstract
The article discusses the clinical variants and manifestations of short bowel syndrome depending on the severity of intestinal failure, as well as approaches to differentiated treatment of this disease. The basic principles of therapeutic nutrition for this category of patients using specialized nutritional formulas are outlined. Features of pharmacotherapy are given depending on the type of development of short bowel syndrome and promising methods of hormonal therapy that can reduce dependence on intravenous support or achieve complete enteral autonomy.
References
Баранская Е.К., Шульпекова Ю.О. Принципы ведения пациентов с синдромом короткого кишечника. Русский медицинский журнал: независимое издание для практикующих врачей. 2010; 18(13): 789–94.
Луфт В.М., ред. Руководство по клиническому питанию. СПб.: Арт-Экспрес; 2023.
Луфт В.М., ред. Справочник по клиническому питанию. СПб.: Премиум Пресс; 2021.
Маевская Е.А., Черёмушкин С.В., Кривобородова Н.А., Кучерявый Ю.А. Синдром избыточного бактериального роста в тонкой кишке: от последних научных данных к рутинной практике. Клинические перспективы гастроэнтерологи, гепатологии. 2013; 5: 29–40.
Соботка Л., ред. Основы клинического питания. Материалы лекций для курсов Европейской ассоциации парентерального питания; пер. с англ. М.; 2015.
Хубутия М.Ш., Попова Т.С., Салтанов А.И., ред. Энтеральное и парентеральное питание. Национальное руководство. М.: ГЭОТАР-Медиа; 2014.
Bakker H., Bozzetti F., Staun M. et al. Home parenteral nutrition in adults: a european multicentre survey in 1997. ESPEN-Home Artificial Nutrition Working Group. Clin Nutr. 1999; 18(3): 135–40. DOI: 10.1054/clnu.1999.0021
Barnadas G. Navigating home care: parenteral nutrition — part two. Pract Gastroenterol. 2003; 27: 13–30.
Carbonnel F., Cosnes J., Chevret S. et al. The role of anatomic factors in nutritional autonomy after extensive small bowel resection. JPEN J Parenter Enteral Nutr. 1996; 20(4): 275–80. DOI: 10.1177/0148607196020004275
Chen Y., Tsai Y.H., Tseng B.J., Tseng S.H. Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review. Nutrients. 2019; 11(8): 1941. DOI: 10.3390/nu11081941
DuPont A.W., Sellin J.H. Ileostomy diarrhea. Curr Treat Options Gastroenterol. 2006; 9: 39–48. DOI: 10.1007/s11938-006-0022-7
ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clinical Nutrition. 2015; 34: 171–80. DOI: 10.1016/j.clnu.2014.08.017
Gennari F.J., Weise W.J. Acid-base disturbances in gastrointestinal disease. Clin J Am SocNephrol. 2008; 3: 1861–8. DOI: 10.2215/CJN.02450508
Helmrath M.A., Fong J.J., Dekaney C.M., Henning S.J. Rapid expansion of intestinal secretory lineages following amassive small bowel resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007; 292: 215–22. DOI: 10.1152/ajpgi.00188.2006
Iyer K., Fujioka K., Boullata J. et al. Long-Term Safety and Efficacy With Teduglutide Treatment in Patients With Intestinal Failure Associated With Short Bowel Syndrome (SBS–IF): The STEPS-3 Study. 36th European Society for Clinical Nutrition and Metabolism Congress. Switzerland: Poster presentation. Geneva; September 6–9, 2014.
Jeppesen P.B., Pertkiewicz M., Forbes A. et al. Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide — analyses from a randomised, placebo-controlled study. Clin Nutr. 2013; 32(5): 713–21. DOI: 10.1016/j.clnu.2013.03.016
Jeppesen P.B. Spectrum of Short Bowel Syndrome in Adults: Intestinal Insufficiency to Intestinal Failure. Journal of Parenteral and Enteral Nutrition. 2014; 38(1): 8–13. DOI: 10.1177/0148607114520994
Kelly D.G., Tappenden K.A., Winkler M.F. Short bowel syndrome: highlights of patient management, quality of life, and survival. JPEN J Parenter Enteral Nutr. 2014; 38(4): 427–37. DOI: 10.1177/0148607113512678
Pironi L., Joly F., Forbes A. et al. Long-term follow-up of patients on home parenteral nutrition in Europe: implications for intestinal transplantation. Gut. 2011; 60: 17–25. DOI: 10.1136/gut.2010.223255
Shaffer J. Intestinal failure: definition and service development. ClinNutr. 2002; 21(Suppl.1): 144e5.
Staun M., Pironi L., Bozzetti F. et al. ESPEN Guidelines on Parenteral Nutrition: Home Parenteral Nutrition (HPN) in adult patients. Clinical Nutrition. 2009; 28: 467–79. DOI: 10.1016/j.clnu.2009.04.001
Wengler A., Micklewright A., Heґbuterne X. et al. Home parenteral nutrition teaching practice in Europe. ClinNutr. 2002: 21–42.