PROVISION OF FAT-SOLUBLE VITAMINS IN THE BODY OF THE ADULT POPULATION OF RESIDENTS OF SAINT PETERSBURG

  • G.G. Rodionov Center for Emergency and Radiation Medicine named after A.M. Nikiforov. 4/2 Akademician Lebedev str., Saint Petersburg 197345 Russian Federation https://orcid.org/0000-0001-6237-7848
  • I.I. Shantyr Center for Emergency and Radiation Medicine named after A.M. Nikiforov. 4/2 Akademician Lebedev str., Saint Petersburg 197345 Russian Federation
  • E.V. Svetkinа Center for Emergency and Radiation Medicine named after A.M. Nikiforov. 4/2 Akademician Lebedev str., Saint Petersburg 197345 Russian Federation
  • E.A. Kolobova Center for Emergency and Radiation Medicine named after A.M. Nikiforov. 4/2 Akademician Lebedev str., Saint Petersburg 197345 Russian Federation
  • Yu.A. Fominykh V.A. Almazov National Medical Research Center. Akkuratova str., 2, Saint Petersburg, Russian Federation, 197341
  • K.N. Nadzhafova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
Keywords: nutrition, physiological need, vitamins (A, E, D3), chromatography-mass spectrometry, hypovitaminosis, deficiency

Abstract

Introduction. Nutrition makes the greatest contribution to ensuring human health and performance from the sum of all factors affecting lifestyle. The aim of the study is to assess the provision of fat-soluble vitamins in the body of adult residents of St. Petersburg of different genders and ages. Materials and methods. The objects of the study were 816 residents of St. Petersburg of different genders and ages, in whom, from 2018 to 2023, fat-soluble vitamins were determined in blood plasma on the basis of the chromato-mass-spectrometry laboratory of the Department of Bioindication of Center for Emergency and Radiation Medicine named after A.M. Nikiforov. The following age and sex groups were identified: men and women 18–29 years old, 30–44 years old, 45–64 years old. Chromatography-mass spectrometric determination of the concentration of fat-soluble vitamins (A, E, D3) in blood plasma was performed. Results. In women, compared with men, there was a statistically significant decrease in vitamin E levels by 29 %, vitamin A by 17 % and an increase in vitamin 25-OH-D3 levels by 18 %. The greatest deficiency in the body of residents of St. Petersburg of different genders and ages was revealed in the content of vitamin 25-OH-D3 (48 %) and vitamin E (27 %). At the same time, women had a greater deficiency of vitamin E (44%) and vitamin A (14 %) compared to men, and men had a greater deficiency of vitamin 25-OH-D3 (53 %). Conclusions. The data obtained indicate a pronounced deficiency of vitamin 25-OH-D3 and a moderate deficiency of vitamin E in the body of residents of St. Petersburg of different genders and ages. At the same time, women had a greater deficiency of vitamin E and A compared to men, and men had a greater deficiency of vitamin 25-OH-D3. The replenishment of fat-soluble vitamins, especially vitamin 25-OH-D3, can become an important additional method of disease prevention in residents of St. Petersburg.

References

Брещенко Е.Е., Мелконян К.И. Биологически активные вещества. Витамины, ферменты, гормоны: учебно-методическое пособие. Под редакцией проф. И.М. Быкова. Краснодар; 2019.

Дефицит витамина D у взрослых: диагностика, лечение и профилактика. Учебное пособие. Клинические рекомендации Российской ассоциации эндокринологов. М.–Тверь: Триада; 2020.

Методические рекомендации. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. 2021.

Нутрициология и клиническая диетология. Национальное руководство 2-е издание. Под редакцией академика РАН В.А. Тутельяна, члена-корреспондента РАН Д.Б. Никитюка. М.: ГЭОТАР-Медиа; 2021.

Родионов Г.Г., Шантырь И.И., Ушал И.Э., и соавт. Диагностика оксидативного стресса у пожарных и спасателей МЧС России. Мед.-биол. и соц.-психол. пробл. безопасности в чрезв. ситуациях. 2019; 2: 104–10. DOI: 10.25016/2541-7487-2019-0-2-104-110.

Формирование стандарта диагностики оксидативного стресса при обследовании сотрудников ГПС МЧС России. Под ред. профессора С.С. Алексанина. СПб.: ВЦЭРМ им. А.М. Никифорова МЧС России; 2019.

Argano C., Mirarchi L., Amodeo S. et al. The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art. Int J Mol Sci. 2023; 24(20): 15485. DOI: 10.3390/ijms242015485.

Barbarawi M., Zayed Y., Barbarawi O. et al. Effect of Vitamin D supplementation on the incidence of diabetes mellitus. J. Clin. Endocrinol. Metab. 2020: 105. DOI:10.1210/clinem/dgaa335.

Bartosinska E., Buszewska-Forajta M., Siluk D. GC-MS and LC-MS approaches for determination of tocopherols and tocotrienols in biological and food matrices. J. of Pharmaceutical and Biomedical Analysis. 2016; 127: 156–69. DOI:10.1016/j.jpba.2016.02.051.

Fronczek M., Osadnik T., Banach M. Impact of vitamin D receptor polymorphisms in selected metabolic disorders. Curr Opin Clin Nutr Metab Care. 2023; 26(4): 316–22. DOI:10.1097/MCO.0000000000000945.

Galunska B.T., Gerova D.I., Boncheva M.I., Svi­narov D.A. HPLC method for measuring the circulating levels of 25-hydroxy vitamin D: Validation and comparison with ID LC/MS/MS and immunoassay. Integr Food Nutr Metab. 2014; 1(2): 119–23. DOI:10.15761/IFNM.1000112.

Golzarand M., Hollis B.W., Mirmiran P. et al. Vitamin D supplementation and body fat mass: a systematic review and meta-analysis. Eur. J. Clin. Nutr. 2018; 72: 1345–57. DOI: 10.1038/s41430-018-0132-z.

Lemieux P., Weisnagel S.J., Caron A.Z. et al. Effects of 6-Month Vitamin D supplementation on insulin sensitivity and secretion: a randomised, placebo-controlled trial. Eur. J. Endocrinol. 2019; 181: 287–99.

Mansouri M., Abasi R., Nasiri M. et al. Association of Vitamin D status with metabolic syndrome and its components: a cross-sectional study in a population of high educated iranian adults. Diabetes Metab. Syndr. 2018; 12: 393–8. DOI:10.1016/j.dsx.2018.01.007.

Melguizo-Rodriguez L., Costela-Ruiz V.J., Garcia-Recio E. et al. Role of Vitamin D in the Metabolic Syndrome. Nutrients. 2021; 13(3): 830. DOI: 10.3390/nu13030830.

Perna S. Is Vitamin D supplementation useful for weight loss programs? A Systematic review and meta-analysis of randomized controlled trials. Medicina. 2019; 55. DOI: 10.3390/medicina55070368.

Safarpour P., Daneshi-Maskooni M., Vafa M. et al. Vitamin D supplementation improves sirt1, irisin, and glucose indices in overweight or obese type 2 diabe­tic patients: a double-blind randomized placebo-controlled clinical trial. BMC Fam. Pract. 2020; 21: 26. DOI:10.1186/s12875-020-1096-3.

Published
2024-09-30
How to Cite
Rodionov, G., Shantyr, I., SvetkinаE., Kolobova, E., Fominykh, Y., & Nadzhafova, K. (2024). PROVISION OF FAT-SOLUBLE VITAMINS IN THE BODY OF THE ADULT POPULATION OF RESIDENTS OF SAINT PETERSBURG. University Therapeutic Journal, 6(2), 128-139. https://doi.org/10.56871/UTJ.2024.17.90.014
Section
Статьи