ASSESSMENT OF BIOMARKERS OF SYSTEMIC INFLAMMATION IN ELDERLY WOMEN WITH KNEE OSTEOARTHRITIS
Abstract
Osteoarthritis (OA) is a chronic disease associated with age, gender, metabolic
disorders, genetic and biochemical factors, characterized by joint destruction, bone hyperplasia and
degeneration of articular cartilage due to inflammatory pathogenetic mechanisms. Hematological
indices of cellular reactivity (the ratio of the number of lymphocytes, neutrophils, monocytes and
platelets) change significantly during systemic inflammation, which justifies the interest in their
study in osteoarthritis of the knee joint (OAK). However, these indices have not been studied in elderly women with varying degrees of severity of OAK. The aim of the study was to compare the levels of markers of systemic inflammation depending on the severity of OAK (according to Kellgren and Lawrence) in elderly women. Materials and methods. The study included 86 women with OAK at the age of 69±3 years. Results. Atients with grade III ОAC have been identified higher levels of monocytes (18.6%, p <0.01), NLR (neutrophil/lymphocyte ratio) indices (15.6%, p <0.05), MLR (monocyte/lymphocyte ratio) (29.6%, p <0.01), PLR (platelet/lymphocyte ratio) (12.6%, p <0.05), BSR (26.7%, p <0.01), CRP (C-reactive protein) (24.5%, p <0.01), MCP-1 (monocyte chemotactic protein-1) (20.2%, p <0.01) and lower lymphocyte values (11.1%, p <0.05) than with I–II degrees of severity. Correlation analysis showed the presence of a positive association of BSR with the level of NLR (r=0.215, p=0.021), MLR (r=0.223, p=0.017), PLR (r=0.1199, p=0.033), CRP with NLR (r=0.223, p=0.017), MLR (r=0.328, p <0.001), PLR (r=0.190, p=0.042), MCP-1 with MLR (r=0.213, p=0.022). Conclusions. The high positive correlation between MLR, NLR, PLR, and BSR, CRP, MCP-1 and the absence of correlation with age indicates that MLR and NLR in combination with BSR and CRP, MCP-1 may be predictors of the severity of OAK.
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