THE ROLE OF THE CLOTHO PROTEIN IN PATHOGENESIS OF CERTAIN DISEASES. LITERATURE REVIEW
Abstract
The review article is devoted to the effect of Clotho protein on the occurrence and course of certain diseases (arterial hypertension, chronic kidney disease, oncological diseases). The Kloto gene is localized in chromosomes 5, 12 and 13 and consists of a coding sequence in the form of five exons and four introns, expressed in the largest volume by distal renal tubules. Clotho protein belongs to the class of hormonal proteins, it determines the functions and condition of many metabolic processes, some ion channels, and a number of organs — the parathyroid gland, liver, heart, and pancreas. The expression of the Clotho protein is dynamically regulated depending on external factors, age and the presence of diseases, and the mechanisms of regulation of its synthesis are of great interest. The results of clinical studies devoted to the study of Clotho protein show that a significant number of pathological conditions are accompanied by a decrease in its synthesis. These include nephropathies of various origins, hypertension and diabetes mellitus. This review is devoted to detailing the possible mechanisms of the influence of the Clotho protein on the development of this nosology.
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