REDUCTION OF INSTRUMENTAL FUNCTIONAL ACTIVITY IN PATIENTS WITH SARCOPENIC OBESITY AND AGE-ASSOCIATED PATHOLOGY OF THE ORGAN OF VISION

  • N.M. Agarkov S.N. Fedorov National medical research center “Intersectoral Scientifi c and Technical Complex Eye Microsurgery”, Tambov branch. 1 Rasskazovskoe highway, Tambov 392000 Russian Federation https://orcid.org/0000-0002-4821-3692
  • A.E. Kopylov S.N. Fedorov National medical research center “Intersectoral Scientifi c and Technical Complex Eye Microsurgery”, Tambov branch. 1 Rasskazovskoe highway, Tambov 392000 Russian Federation
  • V.V. Aksenov Southwest State University. 94, 50 years of October str., Kursk 305040 Russian Federation
Keywords: sarcopenic obesity, age-associated pathology of the visual organ, age-related macular degeneration, instrumental activity in everyday life, the elderly, types of limitations in instrumental activity in everyday life

Abstract

Introduction. Sarcopenic obesity in combination with age-associated pathology of the visual organ not only increases the risk of serious complications, but also significantly impairs the functional activity of patients. Aim — to study the effect of sarcopenic obesity and age-associated pathology of the visual organ on the functional abilities of patients. Materials and methods. 132 patients with sarcopenic obesity and 134 patients with sarcopenic obesity and age-related macular degeneration were examined. Criteria recommended by the European Working Group on Sarcopenia in the Elderly (EWGSOP2, 2018) were used to identify sarcopenic obesity. Age-related macular degeneration was diagnosed according to clinical guidelines. The level of instrumental activity in everyday life was assessed using the Lawton scale. Results. Sarcopenic obesity and age–related macular degeneration cause a statistically significant decrease in all types of instrumental activity in everyday life, with the exception of maintaining household life in a house (apartment) — 0.70±0.06 points versus 0.73±0.07 points (p >0.05). It was found that sarcopenic obesity and age-related macular degeneration reduce instrumental activity in daily life to a greater extent (M=4.72±0.07 points) than only sarcopenic obesity (M=5.91±0.09 points) (p <0.001). The greatest differences between the groups in the deterioration of instrumental activity in daily life were observed in such types as making phone calls — 0.57±0.05 points among patients with sarcopenic obesity and age-related macular degeneration and 0.89±0.07 points among patients with sarcopenic obesity by 1.56 times (p <0.001), shopping — 0.62±0.06 and 0.76±0.08 points (p <0.01), financial performance — 0.48±0.05 and 0.61±0.04 points (p <0.001), respectively. Conclusions. The combination of sarcopenic obesity with age-related macular degeneration has a more significant effect on reducing instrumental activity in everyday life and is especially pronounced in using transport, making phone calls, shopping and conducting financial transactions.

References

Baumgartner R.N., Wayne S.J., Waters D.L. et al. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res. 2004;12(12):1995–2004. DOI: 10.1038/oby.2004.250.

Biolo G., Cederholm T., Muscaritoli M. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia. Clin Nutr. 2014;33(5):737–748. DOI: 10.1016/j.clnu.2014.03.007.

Агарков Н.М., Копылов А.Е., Титов А.А. и др. Особенности гериатрического статуса у пациентов с артериальной гипертензией и ишемической болезнью сердца. Научные результаты биомедицинских исследований. 2024;10(1):112–125. DOI: 10.18413/2658-6533-2024-10-1-0-7.

Guthrie D.M., Davidson J.G.S., Williams N. et al. Combined impairments in vision, hearing and cognition are associated with greater levels of functional and communication difficulties than cognitive impairment alone: analysis of interRAI data for home care and long-term care recipients in Ontario. PLoS One. 2018;13(2):e0192971. DOI: 10.1371/journal.pone.0192971.

Sloan F.A., Ostermann J., Brown D.S. et al. Effects of changes in self-reported vision on cognitive, affective, and functional status and living arrangements among the elderly. Am J Ophthalmol. 2005;140(4):618–627. DOI: 10.1016/j.ajo.2005.01.019.

Горелик С.Г., Ильницкий А.Н., Прощаев К.И. и др. Опросники и шкалы в геронтологии и гериатрии. Геронтология. 2021;9(1):1–91.

Cruz-Jentoft A.J., Bahat G., Bauer J. et al. Sarcopenia: revised European consensus on definition and dia­gnosis. Age Ageing. 2019;48(1):16–31. DOI: 10.1093/ageing/afy169.

Donini L.M., Busetto L., Bischoff S.C. et al. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obes Facts. 2022;15(3):321–335. DOI: 10.1159/000521241.

Агарков Н.М., Лев И.В., Копылов А.Е. Биологический возраст как фактор риска офтальмологических осложнений при сахарном диабете 2-го типа. Научные результаты биомедицинских исследований. 2023;9(3):383–392. DOI: 10.18413/2658-6533-2023-9-3-0-8.

Kirk B., Zanker J., Bani H. E. et al. Sarcopenia Definitions and Outcomes Consortium (SDOC) Criteria are Strongly Associated With Malnutrition, Depression, Falls, and Fractures in High-Risk Older Persons. J Am Med Dir Assoc. 2021;22(4):741–745. DOI: 10.1016/j.jamda.2020.06.050.

Long Y., Wu Y., Zhong Y. et al. Resveratrol as a potential therapeutic agent for sarcopenic obesity: Insights from in vivoperiments. Biomed Pharmacother. 2024;179:117396. DOI: 10.1016/j.biopha.2024.117396.

Zhao Q., Zhu Y., Zhao X. et al. Prevalence and risk factors of sarcopenia in patients on maintenance hemodialysis: a retrospective cohort study. BMC Musculoskelet Disord. 2024;25(1):424. DOI: 10.1186/s12891-024-07546-3.

Лев И.В., Агарков Н.М., Стародубцева Л.В. Гериатрическая тактика ведения пациентов с диабетической ретинопатией. Научные результаты биомедицинских исследований. 2023;9(1):129–141. DOI: 10.18413/2658-6533-2023-9-1-0-9.

Katz S., Branch L.G., Branson M.H. et al. Active life expectancy. N Engl J Med. 1983;309(20):1218–1224. DOI: 10.1056/NEJM198311173092005.

Sumukadas D., McMurdo M., Pieretti I., et al. Association between retinal vasculature and muscle mass in older people. Arch Gerontol Geriatr. 2015;61(3):42–58. DOI: 10.1016/j.archger.2015.08.006.

Агарков Н.М., Лев И.В. Османов Р.Э. Влияние сочетанной диабетической ретинопатии и катаракты на инструментальную функциональную активность пациентов. Успехи геронтологии. 2022;35(3):413–417. DOI: 10.34922/AE.2022.35.3.013.

Published
2025-06-11
How to Cite
Agarkov, N., Kopylov, A., & Aksenov, V. (2025). REDUCTION OF INSTRUMENTAL FUNCTIONAL ACTIVITY IN PATIENTS WITH SARCOPENIC OBESITY AND AGE-ASSOCIATED PATHOLOGY OF THE ORGAN OF VISION. University Therapeutic Journal, 7(1), 146-153. https://doi.org/10.56871/UTJ.2025.29.51.013
Section
Original papers