CORRECTION OF HEMATOLOGICAL, CARDIOVASCULAR AND PULMONARY PARAMETERS WITH SUCCINATE PREPARATIONS IN WHITE RATS AFTER MASSIVE BLOOD LOSS

Abstract

Hematologic, biochemical and functional studies of pulmonary, cardiovascular and hematologic systems assessing the effectiveness and safety of infusion therapy with succinate containing medications Cytoflavin and Reamberin in comparison to Mexidol, Cerebrolysin and Sterofundin (35 ml/kg body mass) has been accomplished in an acute massive hemorrhage model in rats. Antioxidant system enzyme activity was assessed. Acute massive hemorrhage pathogenesis in the experimental model utilized includes hypovolemic posthemorrhagic shock and severe posthemorrhagic anemia. The use of the studied medications (Cytoflavin and Reamberin) in comparison to Mexidol, Cerebrolysin and Sterofundin contributed to effective profylaxisand therapy of various organs and systems disorders in the utilized acute experimental model. The use of Cerebrolysin has not demonstrated high effectiveness in the utilized acute pathiologic process model while the safety profile had been maintained. Maximum effectiveness according to integrated therapeutic effects was characteristic of Cytoflavin.