UP-TO-DATE CONCEPT OF NON-ALCOHOLIC FATTY LIVER DISEASE

Abstract

Nonalcoholic fatty liver disease (NAFLD) of late is the most common form of liver lesions. Asymptomatic progress of the disease? Difficulties with its diagnostics and the absence of integrate universal treatment concept are actual challenges demanding deep studies and requiring attention of a wide circle of medical specialists. NAFLD is often manifesting as a component of other ailments like Diabetes mellitus, obesity, contributing to wide spread of cardiovascular diseases (CVD) among population. There are apparent proofs of NAFLD association with metabolic syndrome (MS) and its companents that supposes liver to have a special position among its target organs, it is the first one to undergo characteristic changes accompanied by metabolic impairments in the organism. Dislipoproteinemia plays an important role in the development of MS and other ailments associated with obesity. Pathologic changes of hepatic function are the primeval cause of lipid metabolism impairments hence pathologic functioning of the liver may be independent accessory risk factor for the development of dyslipidemia and obesity as the major component of MS. The review portraaays up to date concepts of NAFLD causes and mechanisms, its interrelations with MS, cardiopulmanory complications and genetical factors.