Hematologic Parameters and the Functional State of the Organism

Abstract

Elaboration of fast and informative methods for the assessment of the organism functional state is an urgent and important issue. General resistance and sensitivity of the organism at various stages of ontogeny are determined by the functional state of all systems’ background level as well as practically always - by the ability to withstand hypoxia, i. e. by the pituitary-adrenal system functional state. Informational significance of certain hematologic parameters associated with resistance to hypoxia and characterizing pituitary-adrenal system functional state was studied. During routine periodic clinical examination individuals aged from zero to 60 years were scrutinized. Peripheral blood RBC, WBC, eozinofils’ number, hemoglobin levels and leukocyte formulas were assessed. Resistance changes should be accompanied by pituitary-adrenal system functional state shifts. The eozinofils number in blood indirectly reflects pituitary-adrenal system functional condition. RBC number and hemoglobin level in peripheral blood also characterize the state of the systems responsible for withstanding haemic hypoxia. Methodic recommendations by L. H. Garkavi et al. (1978) that utilize leukocyte formula as a criterion of the organism functional state gradation were used. We have supplemented this model with hematologic parameters: RBC number, hemoglobin level and eozinofils’ number. The results of the study indicate that hematologic parameters can define the functional state of children under 12 months as “hyperactivation reaction” whereas the state of the adults of 51-60 years may rather be described by “chronic stress” term. A favorable “training reaction” was registered alongside with aging in individuals of 21-50 years of age via “quiet activation” in young persons of 1 to 20 years.