PATHOPHYSIOLOGICAL BASES OF THE PROGRESSION OF METABOLIC DISORDERS AND ATHEROSCLEROSIS IN YOUNG MEN WITH VARIOUS TYPES OF ABDOMINAL OBESITY

Abstract

For the development of preventive medicine, more information is needed about the mechanisms of influence of various types of obesity on the development of metabolic disorders and changes in other systems and organs 3-5 years after their diagnosis. Objective. To clarify the effect of metabolic obesity types on the incidence of diabetes mellitus type 2, prediabetes and atherosclerosis in young men after 3-4 year active observation. Material and methods. Have been examined 93 men aged 30-45 have initially and repeatedly after 3-4 years. Have been evaluated anamnesis morbi, anthropometry, lipid and carbohydrate metabolism; have been investigated echo cardiography and complex intima -media thick ness of the carotid arteries; the frequency of new cases of metabolic syndrome (MS), prediabetes, diabetes mellitus (DM) type 2, subclinical atherosclerosis. It has been formed 4 groups: MS - 25 men, 20 men with metabolically healthy obesity (MHO), 20 men with metabolically neutral obesity (MNO) and 28 people without obesity (control). Results. In dynamics, the frequency of patients with MS increased from 27% (25 men) to 36% (34 patients) the total number of men with MS - 18 people with primary insulin resistance and 16 men from other groups (8 - MHO, 4 - control and MNO). Prediabetes during the initial examination was diagnosed in 15 people (16% of the sample); after curation - 24 cases (26% of the sample). The incidence of atherosclerosis of the carotid arteries increased from 18 (19%) to 37 people (40%). There was detected diabetes mellites type 2 in 3 patients with MS during the observation period. Conclusions. The risk of 3-year development of new cases of prediabetes, diabetes mellites type 2 and atherosclerosis is maximum in patients with insulin resistance and metabolically healthy type of obesity, minimal - with normal body weight and obesity of metabolically neutral type