MAIN DIRECTIONS FOR THE APPLICATION OF THERAPEUTIC HYBERNATION IN CLINICAL AND MILITARY MEDICINE (LITERATURE REVIEW)

  • Alexey E Kim Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
  • Vyacheslav P Ganapolsky Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
  • Konstantin P Golovko Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
  • Evgeny B Shustov Scientific and Clinical Center of Toxicology. acad. S.N. Golikov 192019, Saint-Petersburg
Keywords: hypobiosis, therapeutic hibernation, cryostasis, critical conditions, organ transplantation, controlled hypothermia, shock

Abstract

The article presents an analysis of ways to increase the viability of tissues under conditions of critical hypoxia, associated with a decrease in the oxygen demand of cells. The implementation of these directions of hypobiosis is associated either with a decrease in the temperature of organs and tissues, or with the induction of mechanisms of inhibition of metabolism and energy metabolism, which enhance the effects of controlled hypothermia. The main biological and pathophysiological patterns that characterize the state of tissue hypothermia of varying severity are presented. The main scientific and technical solutions aimed at creating a state of controlled hypothermia (artificial hibernation) in people under critical conditions are given, including methods and devices for cooling the body, compositions and promising directions for the development of a pharmacological group of perfusing hypothermic solutions, means of hibernation induction, devices and methods for cryopreservation of organs. and tissues for transplantation.

Author Biographies

Alexey E Kim, Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
Academician Lebedev str., 6; Senior Researcher
Vyacheslav P Ganapolsky, Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
Academician Lebedev str., 6
Konstantin P Golovko, Military Medical Academy named after S.M. Kirov 194044, Saint-Petersburg
Academician Lebedev str., 6
Evgeny B Shustov, Scientific and Clinical Center of Toxicology. acad. S.N. Golikov 192019, Saint-Petersburg
st. Bekhtereva, 1
Published
2022-09-12
How to Cite
Kim, A. E., Ganapolsky, V. P., Golovko, K. P., & Shustov, E. B. (2022). MAIN DIRECTIONS FOR THE APPLICATION OF THERAPEUTIC HYBERNATION IN CLINICAL AND MILITARY MEDICINE (LITERATURE REVIEW). Russian Biomedical Research, 7(3), 51-61. Retrieved from https://ojs3.gpmu.org/index.php/biomedical-research/article/view/4170
Issue
Vol 7 No 3 (2022)
Section
Статьи

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