FEATURES OF REGULATION OF NEURO-ENDOCRINE AND HUMORAL PROCESSES IN VICTIMS WITH EXTENSIVE BURNS

Abstract

In response to a burn injury in the body, typical pathological processes develop, which include almost all organs and systems, lead to a pronounced disruption of homeostasis, disruption of adaptation mechanisms. A burn is the strongest stress factor causing changes in the body, characteristic of the general adaptation syndrome. The main links of the pathogenesis and characteristics of the course of typical pathological processes in a burn disease are
substantially determined by the endocrine system of the victims. The hormones produced take part not only in the trigger mechanism, but also in the development of compensatory-adaptive reactions, the mobilization of the protective properties of the organism. Thus, the peculiarity of adolescence is that it is at this age that the body undergoes qualitative changes with the restructuring of all systems. Significant morphofunctional alterations of such important in the metabolic supply of the body as the pituitary, adrenal glands, thyroid and pancreas occur, characterized by high activity of metabolic processes, increased cell and tissue differentiation, intensification of regenerative processes. The result is an excessive functional activity of all organs and systems at rest, causing low and often paradoxical reactivity to external influences, including a burn injury, which leads to a decrease in the functional and adaptive capabilities of the body of adolescents. All these features must be considered when choosing a surgical treatment strategy for
people of pubertal age affected by burns.