FEATURES OF DISEASE COURSE AND DYNAMIC OF COMPLICATIONS OF THE BURN DISEASE IN PUBERTY CHILDREN

Abstract

In spite of the progress of surgery and resuscitation and introduction of new innovative methods of treatment of severely burned patients into practical activity, sepsis and multiple organ failure remain the main cause of death regardless of age categories [12]. At the same time, the hematogenous dissemination of microorganisms, which is pathognomonic for the classical picture of sepsis, may be absent or short-term in the septic course of a burn
disease. One of the main links in the pathogenesis of organ-system damage in extensive burns is the uncontrolled spread of pro-inflammatory mediators from the primary focus, leading to the generalization of the inflammatory response. A mediator lesion affects the course of a septicemia or severe sepsis, forming a Systemic inflammatory response syndrome (SIRS) in aseptic course of burn disease, as well as sepsis or severe sepsis (according to the
classification of R. Bone, 1991 — sepsis + MOF) in the case of generalization of infection in severely burned ones. Syndrome of multiple organ failure (MOF) is one of the main complications of burn disease, often leading to the death of victims. The main factors determining the development of the syndrome MOF, are considered: the severity of the thermal injury, the presence of a thermo-chemical lesion of the respiratory tract, the delay in conducting anti-shock therapy, and often the accompanying somatic pathology and the hormonal background of the injured (as applied to
pubertal age).