THE ROLE OF DYSLIPIDEMIA AND INFLAMMATORY PROTEINS IN THE DEVELOPMENT OF ISOLATED VS MULTIFOCAL ATHEROSCLEROTIC PROCESS IN CEREBRAL AND CARDIAC BLOOD VESSELS

Abstract

Nowadays there is an unfavorable trend of increasing incidence of atherosclerosis. The study of risk factors for multifocal lesions of cerebral and cardiac basins is of great scientific and practical interest, since this nosological form is associated with the most severe clinical manifestations - heart attacks and strokes. The study included 207 participants, matched for age: no clinical signs of atherosclerotic lesions, but with their risk factors (hypertension, hypercholesterolemia, obesity) and patients with atherosclerosis. All of them were examined by a program including a survey of complaints, interviewing, anthropometric measurements, and laboratory studies - biochemical blood analysis, performed according to standard procedures with the definition of fractions of cholesterol, triglycerides, fibrinogen, CRP (13 hour starvation). Comparison of the effects of biochemical markers was performed in case of isolated and combined lesions of vessels of head and heart. The results show that at all stages of atherosclerotic process, according to the levels of TC and LDL, no statistically significant differences were detected, which indicates their one-sided directional influence. Elevated titers of cholesterol and LDL have a universal effect on atherosclerotic damage of arteries and severing process is accompanied by a progressive increase in CRP and the atherogenic index, i.e. the mechanism of pathogenic action of the "traditional" risk factors associated with the inflammatory atherosclerotic process. The concentration of inflammatory proteins was significantly higher in manifestation stage with multifocal lesions, and the most dangerous and severe complications of atherosclerosis indicates their joint significant increase. High level of triglycerides is specific for the isolated variants. The results indicate a significant role of atherogenic lipids and high-sensitive inflammatory proteins in the atherosclerotic process that necessitates the establishment and application of risk factors concept as the basis for prevention and related policies in the early diagnosis of severe vascular complications.