Modern views on classification, pathogenesis and treatment of systemic lupus erythematosus

Abstract

The literature review deals with key events in the pathogenesis, new classification criteria and approaches to treatment of the systemic lupus erythematosus. Disrupted processes of programmed cell death (apoptosis, NETosis and autophagy) lead to an increase in the production of apoptotic cells, after which the organism becomes “littered” with further B-cell hyperactivity. Systemic lupus erythematosus (SLE) is the multisystem auto-inflammatory disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. EULAR / ACR2018 introduced new classification criteria for SLE, as well as the ability to treat-to-target therapy with genetic engineering biological agents (GEBA) in order to achieve stable remission and reducing the dosage of glucocorticosteroids, up to their complete abolition