DIAGNOSTIC INFORMATION VALUE OF PRESEPSIN AND TRADITIONAL MARKERS IN THE BLOOD SERUM OF PREMATURE NEWBORNS WITH EARLY NEONATAL SEPSIS

Abstract

We examined 159 children who were treated in the ICU departments - 117 newborns with early NS and 42 healthy children as a reference coghort. All newborns underwent clinical, laboratory and instrumental examination: procalcitonin, C reactive protein, acid base state, bacteriological blood culture, smear from the throat/endotracheal tube, determination of presepsin at birth and in dynamics after 24 and 72 hours. In the etiological structure of sepsis - gram positive bacteria - 71.8%, the proportion of gram negative bacteria was 23.9%, yeast like fungi - 4.4%. The identified microorganisms were sensitive to the antibiotics most often used in clinical practice in newborns: gram positive flora - to sultasin, cefaperzone, gram negative flora - to cefatoxim, cefaperazone, gentamicin, what should be considered when prescribing empirical antibiotic therapy. It was found that the concentration of presepsin increased by more than 5.5 times in the first hours of NS illness, which allows it to be used as an early marker of NS, and a decrease may serve as an indicator of a favorable outcome of the disease.