ТЕЧЕНИЕ И ИСХОДЫ ЛЕЧЕНИЯ ПАЦИЕНТОВ С ТИПИЧНЫМ ГЕМОЛИТИКО-УРЕМИЧЕСКИМ СИНДРОМОМ

Aleksandr L Muzurov; Khadizha M Emirova; Tatiana E Pankratenko; Tatiana Yu Abaseeva; Galina A Generalova; Bobo D Babaev; Malkhaz V Kvaratskheliya; Anatoly V Popa; Sofya A Mstislavskaya; Аlexey D Mayorov

Aleksandr L Muzurov Children’s City Clinical Hospital of St. Vladimir DZM; Russian Medical Academy of Continuing Professional Education 107014, Moscow; 125445, Moscow
Khadizha M Emirova Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow
Tatiana E Pankratenko Children’s City Clinical Hospital of St. Vladimir DZM; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky 107014, Moscow; 129110, Moscow
Tatiana Yu Abaseeva Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow
Galina A Generalova Children’s City Clinical Hospital of St. Vladimir DZM 107014, Moscow
Bobo D Babaev Russian Medical Academy of Continuing Professional Education 125445, Moscow
Malkhaz V Kvaratskheliya Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow
Anatoly V Popa Children’s City Clinical Hospital of St. Vladimir DZM; Russian Research Medical University N.I. Pirogov 107014, Moscow; 117997, Moscow
Sofya A Mstislavskaya Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow
Аlexey D Mayorov Children’s City Clinical Hospital of St. Vladimir DZM 107014, Moscow

Keywords: hemolytic uremic syndrome, acute kidney injury, renal replacement therapy, peritoneal dialysis, hemodialysis, children

Abstract

The article is devoted to an important problem of pediatric resuscitation and nephrology - a typical hemolytic uremic syndrome (tHUS). A retrospective study of 267 patients with tHUS over the past 5 years was carried out. The evaluation of clinical and laboratory data of patients and treatment results was carried out. Mortality was 2.27%. It was revealed that renal replacement therapy was required in 74.5% of patients, the main method of renal replacement therapy (55.3%) was peritoneal dialysis. Anuria at the onset of the disease was an unfavorable factor associated with an increased risk of multiple organ damage, CNS damage, death, as well as prolonged renal replacement therapy and incomplete recovery of kidney function. Anuria is associated with a higher level of markers of inflammation, hemolysis, thrombosis) and a lower level of the C3 component of complement, as well as a longer duration of thrombocytopenia, which allows us to consider these indicators as predictors of the severity of tHUS. The development of acute kidney injury with anuria in patients with tHUS, according to most indicators, significantly worsens the prognosis of patients and is a factor in an unfavorable prognosis in patients with tHUS.

Author Biographies

Aleksandr L Muzurov, Children’s City Clinical Hospital of St. Vladimir DZM; Russian Medical Academy of Continuing Professional Education 107014, Moscow; 125445, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; Smolnaya st., 38; Candidate of Medical Sciences, Head of the Center for Gravitational Blood Surgery and Hemodialysis

Khadizha M Emirova, Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; Delegatskaya st., 20/1

Tatiana E Pankratenko, Children’s City Clinical Hospital of St. Vladimir DZM; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky 107014, Moscow; 129110, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; st. Shchepkina, house 61/2

Tatiana Yu Abaseeva, Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; Delegatskaya st., 20/1

Galina A Generalova, Children’s City Clinical Hospital of St. Vladimir DZM 107014, Moscow

Rubtsovsko-Dvortsovaya st., 1/3

Bobo D Babaev, Russian Medical Academy of Continuing Professional Education 125445, Moscow

Smolnaya st., 38

Malkhaz V Kvaratskheliya, Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; Delegatskaya st., 20/1

Anatoly V Popa, Children’s City Clinical Hospital of St. Vladimir DZM; Russian Research Medical University N.I. Pirogov 107014, Moscow; 117997, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; st. Ostrovityanova, 1

Sofya A Mstislavskaya, Children’s City Clinical Hospital of St. Vladimir DZM; Lomonosov Moscow State University of Medicine and Dentistry A.I. Evdokimova 107014, Moscow; 127473, Moscow

Rubtsovsko-Dvortsovaya st., 1/3; Delegatskaya st., 20/1

Аlexey D Mayorov, Children’s City Clinical Hospital of St. Vladimir DZM 107014, Moscow

Rubtsovsko-Dvortsovaya st., 1/3

THE СOURSE AND OUTCOMES OF TREATMENT OF PATIENTS WITH TYPICAL HEMOLYTIC-UREMIC SYNDROME

Abstract

Author Biographies