INJECTION USE OF PLATELET RICH PLASMA IN THE TREATMENT OF BORDERLINE SKIN BURNS

Abstract

Introduction. The use of platelet-rich plasma is a promising method for treating burn patients. Today, there are many publications devoted to autodermoplasty in combination with the patient’s blood plasma for deep skin burns, but less attention has been paid to the problem of borderline lesions. Оbjective of the study — to evaluate the improvement in the treatment efficacy of burn victims with borderline burns using platelet-rich plasma. Materials and methods. The work demonstrates the results of treatment of 40 patients with borderline skin burns, aged from 18 to 59 years, hospitalized at the State Budgetary Institution of St. Petersburg Research Institute of Emergency Medicine named after. I.I. Janelidze in the period from 2021 to 2023. The criterion for inclusion in the study was the area of a second degree burn wound according to ICD 10, with a total area of up to 15% of the body surface. The results of treatment with platelet-rich plasma were assessed on 2% of the area, which averaged 327.6±15.2 cm2. During the work, clinical, planimetric, cytological and histological research methods were used. Results. Our proposed method of a single injection of platelet-rich plasma into the area of a border burn wound made it possible to accelerate the time for the onset of epithelization by 19.2% (p <0.05), the time for final healing of the wound by 25.1% (p <0.05), and also reduce the incidence of infectious complications by 15% (p <0.05). The obtained clinical and planimetric data were confirmed by cytological and histological studies. In fingerprint smears, by the twelfth day of observation, the number of neutrophils decreased by 33.7% (p <0.05) and the number of fibroblasts and macrophages increased by 41.4% (p <0.05) and 29.3% (p <0.05) respectively. During the histological study, it was noted that the patients in the study group had less pronounced leukocyte infiltration, swelling of the dermis, and a more clearly formed collagen framework. Conclusion. The use of platelet-rich plasma makes it possible to achieve earlier relief of the inflammatory reaction and ensure an earlier transition to the regenerative phase of the wound process in the area of a border burn wound.