EFFECTIVENESS OF ANTI-SHOCK THERAPY IN THE TREATMENT OF EXTENSIVE BURNS IN CASE OF LONG-TERM COMPRESSION SYNDROM

Abstract

The article analyzes the effectiveness of the use of crystalloid and colloid solutions, antihypoxants, antioxidants, and analgesics aimed at relieving the pathological processes of shock development in patients with extensive skin burns against the background of prolonged compartment syndrome. We conducted an experimental study that included 360 adult white outbred rats of both sexes, weighing 220–240 g, divided into groups depending on the treatment method. After modeling long-term compartment syndrome in animals, third-degree burns according to ICD-10 were reproduced, with a total area of 5, 10, 15, 20, 25, 30% of the body surface. The results were assessed after the administration of crystalloid and colloid solutions, as well as any substrate antihypoxants, both based on malic and fumaric acids — reamberin, mafusol, or polyoxyfumarin. As a result of our data, the most optimal statistical group of animals in the experiment was identified, with a skin burn area of 15% and the presence of long-term compression syndrome. During the study, the optimal volume of antishock infusion therapy was determined, which exceeded the calculated volume of infusions on the first day based on the Parkland scheme by almost 40% (p <0.01).