SKIN MICROBIOTA AND ITS INFLUENCE UPON THE DEVELOPMENT OF ATOPIC DERMATITIS
Abstract
Human skin is the largest organ that performs many functions. Skin condition significantly affects the quality of human life. Modern allergology and dermatology have made significant progress in diagnosing and treating skin diseases. Skin is a habitat for various populations of microorganisms: viruses, bacteria, fungi. Changes in the microbial composition of the skin affect its functional component. Skin microbiota can change under the influence of various factors: gender, age, used care products. Skin diseases can occur due to the influence of exogenous factors (physical, mechanical, chemical, biological and infectious). Cosmetics have the most adverse effect on skin microbiota in the modern world. Cosmetics affect the structure of the microorganisms themselves on the surface of the dermis. In addition to exogenous factors, endogenous factors that can change the condition of the skin also participate in changing the microbiological composition of the skin: blood diseases, immunodeficiency states, stress, genetic factors and intercurrent diseases. In modern studies, more and more attention is paid to the study of the role of human skin microbiota in the development of a number of dermatoses: atopic dermatitis. In atopic dermatitis, the number of S.aureus and S.epidermidis increases. Patients with AD have weakened skin immunity due to the activity of S.aureus. The review also presents modern data on the composition of healthy skin microbiota, and demonstrates the mechanisms of its influence on the course of various diseases. The role of microbiota imbalance in the development of chronic skin diseases, including atopic dermatitis, is analyzed.
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