УНИКАЛЬНОСТЬ СОСТАВА КОЗЬЕГО МОЛОКА И ПРЕИМУЩЕСТВА ИСПОЛЬЗОВАНИЯ ФОРМУЛ НА ЕГО ОСНОВЕ У МЛАДЕНЦЕВ, ЛИШЕННЫХ ГРУДНОГО МОЛОКА

  • Наталья Михайловна Богданова Санкт-Петербургский государственный педиатрический медицинский университет. 194100, Российская Федерация, г. Санкт-Петербург, ул. Литовская, д. 2 https://orcid.org/0000-0002-4516-4194
Ключевые слова: грудное молоко, коровье молоко, козье молоко, αS1-казеин, αS2-казеин, β-казеин, β-казоморфин, олигосахара, адаптированная молочная формула

Аннотация

В статье представлен обзор научной литературы по особенностям состава козьего молока. Отмечено, что цельное молоко любых сельскохозяйственных животных, в том числе и коз, не рекомендовано для употребления детьми грудного возраста, так как их состав не соответствует грудному молоку и организм младенцев не способен к адекватному перевариванию и усвоению филогенетически не предусмотренной пищи. Отражено, что применение инновационных технологий при производстве адаптированных молочных формул на основе козьего молока для младенцев позволяет сохранить все естественные ценные компоненты сырья. Приведены клинические исследования, подтверждающие эффективность использования стартовых формул на основе козьего молока.

Литература

Barker DJP. Sir Richard Doll Lecture. Developmental origins of chronic disease. Public Health. 2012;126:185–189.

Frolova N.I., Buldakova L.R. Elixir of health. Practical dietology. 2012;3:58–63.

Haenlein GFW. Goat milk in human nutrition. Small Rumin. Res. 2004;51:155–163.

Lowenstein M, Speck SJ, Barnhart HM, Frank JF. Research on goat milk products: A review. J. Dairy Sci. 1980;63:1631–1648.

Haenlein GFW. Past, present, and future perspectives of small ruminant dairy research. J. Dairy Sci. 2001;84(11573791):2097–2115.

Høst A. Frequency of cow's milk allergy in childhood. Ann. Allergy Asthma Immunol. 2002; 89(12487202):33–37.

Jenness R. Composition and characteristics of goat milk: Review 1968–1979. J. Dairy Sci. 1980;63:1605–1630.

Ballabio C., Chessa S., Rignanese D., Gigliotti C., Pagnacco G., Terracciano L., Fiocchi A., Restani P., Caroli AM. Goat milk allergenicity as a function of αs1-casein genetic polymorphism. J. Dairy Sci. 2011;94(21257068):998–1004.

Villa C., Costa J., Oliveira M., Mafra I. Comprehensive Reviews in Food Science and Food Safety. 2018;17:137–164.

Lisson M., Novak N., Erhardt G. Immunoglobulin E epitope mapping by microarray immunoassay reveals differences in immune response to genetic variants of caseins from different ruminant species. J. Dairy Sci. 2014;97(24485684):1939–1954.

Баранов А.А., Намазова-Баранова Л.С., Хаитов Р.М. и др. Современные принципы ведения детей с пищевой аллергией. Педиатрическая фармакология. 2021;18(3):245–263. DOI: 10.15690/pf.v18i3.2286.

Аллергия к белкам коровьего молока у детей. Клинические рекомендации. Утвержденные Сою­зом педиатров России. 2018.

Stergiadis S., Nørskov N.P., Purup S., Givens I., Lee MRF. Comparative Nutrient Profiling of Retail Goat and Cow Milk. Nutrients. 2019;11(10):2282.

Pintado M.E. & Malcata F.X. Hydrolysis of ovine, caprine and bovine whey proteins by trypsin and pepsin. Bioprocess Engineering. 2000;23:275–282.

Bevilacqua C et al. Goats’ milk of defective alpha(s1)-casein genotype decreases intestinal and systemic sensitisation to beta-lactoglobulin in guinea pigs. Journal of Dairy Research. 2001;68:217–227.

Martin P., Addeo P. Genetic polymorphism of casein in the milk of goats and sheep. in: Production and Utilization of Ewe and Goat Milk; Proc. IDF/Greek National Committee of IDF/CIRVAL Seminar, Crete, Greece. 1996:45–58.

Clark S., Sherbon J.W. Genetic variants of alphaS1-CN in goat milk: Breed distribution and associations with milk composition and coagulation properties. Small Rumin. Res. 2000;38:135–143.

Caroli A., Chiatti F., Chessa S., Rignanese D., Bolla P., Pagnacco G. Focusing on the goat casein complex. J. Dairy Sci. 2006;89(16840635):3178–3187.

Cebo C., López C., Henry C., Beauvallet C., Ménard O., Bevilacqua C., Bouvier F., Caillat H., Martin P. Goat αs1-casein genotype affects milk fat globule physicochemical properties and the composition of the milk fat globule membrane. J. Dairy Sci. 2012;95(22921619):6215–6229.

Хавкин А.И., Васиа М.Н., Новикова В.П. Биологическая роль казоморфинов (часть 1). Экспериментальная и клиническая гастроэнтерология. 2021;12 (196):102–109.

Хавкин А.И., Васиа М.Н., Завьялова А.Н., Новикова В.П. Переваривание белков, казоморфины и кисломолочные продукты. Вопросы практической педиатрии. 2021;16(5):125–133.

Ковалюк Н.В., Якушева Л.И., Шахназарова Ю.Ю., Кесем А.А. Сборник науч. трудов СКНИИЖ. 2019;8:4–8.

Demmelmair H., Prell C., Timby N., Lönnerdal B. Nut­rients. 2017:9:817.

Boutrou R., Gaudichon C., Dupont D., Jardin J., Airinei G., Marsset-B aglieri A. et al. Sequential release of milk protein- derived bioactive peptidesin the jejunum in healthy humans. Am J Clin Nutr. 2013;97(6):1314–1323.

Aadland E., Fagerhol M.K. Faecal calprotectin: a marker of inflammation throughout the intestinal tract. Eur J Gastroenterol Hepatol. 2002;14(8):823–825.

Хавкин А.И., Васиа М.Н., Новикова В.П. Биологическая роль казоморфинов (часть 2): роль в патологии человека. Экспериментальная и клиническая гастроэнтерология. 2021;12(196):110–118.

Chia JSJ., McRae J.L., Kukuljan S., Woodford K., Elliott R.B., Swinburn B., Dwyer K.M. A1 beta-casein milk protein and other environmental pre-dis-posing factors for type 1 diabetes. Nutr Diabetes. 2017;7:e274.

Kamiński S., Cieslińska A., Kostyra E. Polymor­p­hism of bovine beta-casein and its potential effect on human health. J Appl Genet. 2007;48(3):189–198.

Jasińska B. The comparison of pepsin and trypsin action on goat, cow, mare and human caseins. Rocz. Akad. Med. Bialymst. 1995;40:486–493.

Darragh A. The assessment of protein quality of goat and cow milk. Presented to the Perinatal Society of Australia and New Zelandand in Adelaide. 2005.

Prosser C. Characteristic and benefits of goat milk as a base for infant formula. Paper presented at the Korean Society of Pediatric: Gastroenterology and Nutrition Conference, Seul, Korea. 2004.

Prosser C. Bioactive components of goat milk

compared to human milk. Poster paper presen­ted at the Perinatal Society of Australia and New Zealand (PSANZ) Conference, Adelaide, Australia. 2005.

Mehaia M.A., Al-Kanhal M.A. Taurine and other free amino-acids in milk of camel, goat, cow and man. Milchwissenschaft. 1992;47:351–353.

Militante J.D., Lombardini L.B. Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids. 2002;23:381–393.

Warskulat U., Flogel U., Jacoby C., Hartwig H.G., Thewissen M., Merx M.W., Molojavyi A., Heller-Stilb B., Schrader J., Haussinger D. Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. 2004. DOI:10.1096/fj.03-0496fje.

Penttila I.A. et al. Immune modulation in suckling rat pups by a growth factor extract derived from milk whey. Journal of Dairy Research. 2001;68:587–599.

Stavnezer J. Regulation of antibody production and class switching by TGF-beta. Journal of Immunology. 1995;155:1647–1651.

Murphy M.S. Growth factors and the gastrointestinal tract. Nutrition. 1998;14:771–774.

Politis I., White J.H., O'Hare K., Zavizion B., Gilmore J., Caler W. Distribution of plasminogen ­activator forms in fractions of goat milk. J. Dairy Sci. 1994;77(7836578): 2900–2906.

Trujillo A.J., Guamis B., Carretero C. Hydrolysis

of caprine β-casein by plasmin. J. Dairy Sci. 1997;80(9361197):2258–2263.

Baldi A., Savoini G., Cheli F., Fantuz F., Senato-

re E., Bertocchi L., Politis I. Changes in plasmin-plasminogen-plasminogen activator in milk from Italian dairy cows. Int. Dairy J. 1996;6:1045–1053.

Wang Z., Jiang S., Ma C., Huo D., Peng Q., Shao Y., Zhang J. Evaluation of the nutrition and function of cow and goat milk based on intestinal microbiota by metagenomic analysis. Food Funct. 2018;9(4):2320–2327.

Bhavaniramya S., Sibiya A., Alothaim A.S., Al Othaim A., Ramar V., Veluchamy A., Manikandan P., Vaseeharan B. Evaluating the structural and immune mechanism of Interleukin-6 for the investigation of goat milk peptides as potential treatments for COVID-19. J King Saud Univ Sci. 2022;34(4):101924.

Cerbulis J., Parks O.W., Farrell Jr., H.M. Composition and distribution of lipids of goats’ milk. J. Dairy Sci. 1982;65:2301–2307.

Jenness R., Parkash S. Lack of a fat globule cluste­ring agent in goats' milk. J. Dairy Sci. 1971;54:123–126.

Сагитова Г.Р., Антонова А.А., Давыдова О.В. и др. Естественное вскармливание детей пер­вого года жизни. Астраханский медицинский журнал. 2022;17(3):60–65. DOI: 10.48612/agmu/2022.17.3.60.65.

Tappenden K.A., Thomson A.B., Wild G.E., McBurney M.I. Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats. Gatroenterology. 1997;112:792–802.

Chilliard Y., Ferlay A., Rouel J., Lamberet G. A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis. J. Dairy Sci. 2003;86(12778586): 1751–1770.

Martinez-Ferez A., Rudloff S., Guadix A., Henkel C.A., Pohlentz G., Boza J.J., Guadix E.M., Kunz C. Goat’s milk as a natural source of lactose-derived oligosaccharides: Isolation by membrane techno­logy. Int. Dairy J. 2005;16:173–181.

Viverge D., Grimmonprez L., Solere M. Chemical characterization of sialyl oligosaccharides isolated from goat (Capra hircus) milk. Bioch. Biophys. Acta Gen. Sub. 2007;1336:157–164.

Meyrand M., Dallas D.C., Caillat H., Bouvier F., Martin P., Barile D. Comparison of milk oligosaccharides between goats with and without the genetic ability to synthesize αs1-casein. Small Rumin Res. 2013;113(2–3):411–420.

Giorgio D., Di Trana A., Claps S. Oligosaccharides, polyamines and sphingolipids in ruminant milk. Small Rumin Res. 2018;160:23–30.

Leong A., Liu Z., Almshawit H., Zisu B., Pillidge C., Rochfort S., Gill H. Oligosaccharides in goats’ milk-based infant formula and their prebiotic and anti-infection properties. Br J Nutr. 2019;122(4):441–449.

Boehm G., Stahl B. Oligosaccharides from Milk. J. Nutr. 2007;137:847S–849S.

Daddaoua A., Puerta V., Requena P., Martinez-

Fe­rez A., Guadix E., de Medina F.S., Zarzuelo A.,

Sua­rez M.D., Boza J.J., Matinez-Augustin O. Goat milk oligosaccharides are antiinflammatory in rats with hapten-induced colitis. J. Nutr. 2006;136:672–676.

Lara-Villoslada F., Debras E., Nieto A., Concha A., Galvez J., Lopez-Huertas E., Boza J., Obled C., Xaus J. Oligosaccharides isolated from goat milk reduce intestinal inflammation in a rat model of dextran sodium sulfate-induced colitis. Clin. Nutr. 2006;25:477–488.

Конь И.Я. Козье молоко в питании детей раннего возраста. Детский доктор. 2000;2:55–58.

Juarez M., Ramos M. Physico-chemical characteristics of goat milk as distinct from those of cow's milk. Int. Dairy Fed. Buffl. 1986;202:54–67.

Parkash S., Jenness R. The composition and cha­racteristic's of goat milk: a review. Dairy Sci. Aabstr. 1968;30:67–87.

Park Y.W., Mahoney A.W., Hendricks D.G. Bioavailability of iron in goat milk compared with cow milk fed to anaemic rats. J. Dairy Sci. 1986;69:2608–2615.

Lopez A.I., Alférez MJM., Barrionuevo M., Lisbona F., Campos M.S. Influence of goat and cow milk on digestion and metabolic utilization of calcium and iron. J. Physiol. Biochem. 2000;56(3):201–208.

Национальная Программа оптимизации вскармливания детей первого года жизни в РФ. М.; 2019.

Elvehjem C.A. What is new in the nutritive value of milk. J. Dairy Sci. 1953;36:1264–1266.

Davidson G.P., Townley RRW. Structural and functional abnormalities of the small intestine due to nutritional folic acid deficiency in infancy. J. Pediatr. 1977;90(557084):590–594.

Ziegler D.S., Russell S.J., Rozenberg G., James C.A., Trahair T.N., O'Brien T.A. Goats' milk quackery. J. Paediatr. Child Health. 2005;41(16398839):569–571.

Basnet S., Schneider M., Gazit A., Mander G., Doctor A. Fresh goat's milk for infants: Myths and realities. Pediatrics. 2010;125(20231186):e973-e977.

Clark S, García MBM. A 100-Year Review: Advances in goat milk research J Dairy Sci. 2017;100(12):10026–10044.

Rollins N., Piwoz E., Baker P., Kingston G., Mabaso K.M., McCoy D., Ribeiro Neves P.A., Pérez-­Escamilla R., Richter L., Russ K. et al. Marketing of commercial milk formula: A system to capture parents, communities, science, and policy. Lancet. 2023;401:486–502.

Baker P., Smith J.P., Garde A., Grummer-Strawn L.M., Wood B., Sen G., Hastings G., Pérez-Escamilla R., Ling C.Y., Rollins N. et al. The political economy of infant and young child feeding: Confronting corporate power, overcoming structural barriers, and accelerating progress. Lancet. 2023;401:503–524.

Pérez-Escamilla R., Tomori C., Hernández-Cordero S., Baker P., Barros AJD., Bégin F., Chapman D.J., Grummer-Strawn L.M., McCoy D., Menon P. et al. Breastfeeding: Crucially important, but increa­singly challenged in a market-driven world. Lancet. 2023;401:472–485.

Федеральная служба государственной статистики. https://rosstat.gov.ru/folder/13721.

Грудное вскармливание в России. Итоговый отчет. Демоскоп Weekly. 2015;651-652. http://www.demoscope.ru/weekly/2015/0651/reprod02.php.

Ладодо О.Б., Жданова С.И., Зубков В.В., Кодинцова В.М., Дегтярев Д.Н., Рюмина И.И., Салагай О.О., Шешко Е.Л. Грудное вскармливание в России: проблемы и перспективы. Общественное здоровье. 2023,3(1):18–32. DOI: 10.21045/2782-1676-2023-3-1-18-32.

Гурова М.М. Смеси на основе козьего молока. Кому, зачем, как. Медицинский совет. 2022;16(1):128–133.

Sepe L., Argüello A. Recent advances in dairy goat products. Asian-Australas. J. Anim. Sci. 2019;32:1306–1320.

Miller B.A., Lu C.D. Current status of global dairy goat production: An overview. Asian-Australas. J. Anim. Sci. 2019;32:1219–1232.

Новикова В.П., Гурова М.М., Завьялова А.Н., Маталыгина О.А., Богданова Н.М., Яковлева М.Н., Турганова Е.А., Иванов Д.О. Навигатор по продуктам питания детей раннего возраста. В помощь практикующему педиатру учебное пособие в 3 томах/ Навигатор по специализированным продуктам для кормящих женщин и детским формулам для вскармливания детей от рождения до 3 лет. Том 1. СПб.; 2022.

European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA) Scientific Opinion on the suitability of goat milk protein as a source of protein in infant formulae and in follow-on formulae. EFSA J. 2012;10:2603. DOI: 10.2903/j.efsa.2012.2603.

Higgins JPT., Thomas J., Chandler J., Cumpston M., Li T., Page MJ., Welch V.A., editors. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022). Cochrane, 2022. (accessed on 27 January 2023). Available online: www.training.cochrane.org/handbook.

Page M.J., McKenzie J.E., Bossuyt P.M., Boutron I., Hoffmann T.C., Mulrow C.D., Shamseer L., Tetzlaff J.M., Akl E.A., Brennan S.E. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Jankiewicz M., van Lee L., Biesheuvel M., Brou­-

wer-Brolsma E.M., van der Zee L., Szajewska H. The Effect of Goat-Milk-Based Infant Formulas

on Growth and Safety Parameters: A Systematic Review and Meta-Analysis. Nutrients. 2023;15(9):2110.

Kumar S., Birendra K., Rajesh K., Suryamani K. Featur Eatures Nutritional F Eatur Es of Goat Milk Review Eview. Indian Journal Dairy Science. 2012;65(4):266–273.

Abbas H., Hassan F.H., Abd El-Gawad Enab A. Phy­sicochemical Characteristics of goat’s milk. Igarss. 2014;11(1):307–317.

Grant C., Rotherham B., Sharpe S., Scragg R., Thompson J., Andrews J., Wall C., Murphy J., Lowry D. A randomised, double-blind comparison of goat milk and cow milk infant formula. Journal of Paediatrics and Child Health. 2005;41:564–568.

Prosser C., McLaren R., Ruther ford S., Hendriks A., Lowry D. Digestion of milk proteins from cow or goat milk infant formula. Abstract of poster paper presented by Dr Colin Prosser at the Paediatric Society of New Zealand. 56th Annual Scientific Mee­ting, Queenstown. 2003.

Beauchamp G.K., Mennella J.A. Flavor Perception in Human Infants: Development and Functional Significance. Digestion. 2011;83,1–6.

Nicklaus S. The Role of Dietary Experience in the Development of Eating Behavior during the First Years of Life. Ann. Nutr. Metab. 2017;70,241–245.

Mennella J.A., Beauchamp G.K. Flavor experiences during formula feeding are related to preferences during childhood. Early Hum. Dev. 2002;68,71–82.

Epifanio M., de Abreu CLM., Barros K., Oviedo J., Covic A., Ormenese RCS. Palatability and Sensory Perception of Infant Formulas for the Treatment of Cow’s Milk Allergy According to Brazilian Mothers. Biomed. J. Sci. Tech. Res. 2020;25:18803–18810.

Jung C., González Serrano A., Batard C., Seror E., Gelwane G., Poidvin A., Lavallée I., Elbez A., Brussieux M., Prosser C., Gallier S., Bellaïche M. Whole Goat Milk-Based Formula versus Whey-Based Cow Milk Formula: What Formula Do Infants Enjoy More?-A Feasibility, Double-Blind, Randomized Controlled Trial. Nutrients. 2023;15(18):4057.

Young W. Park, Goat Milk: Composition, Characteristics. Encyclopedia of Animal Science. January 2010. In book: Encyclopedia of Animal Science, Edition: 2nd Chapter: Goat Milk: Composition, Characteristics. Publisher: CRC Press.

Harden C.J. and Hepburn N.J. The benefits of consuming goat’s milk. 2011.

Stergiadis S., Berlitz C.B., Hunt B., Garg S., Ian Givens D., Kliem K.E. An update to the fatty acid profiles of bovine retail milk in the United Kingdom: Implications for nutrition in different age and gender groups. Food Chem. 2019;276:218–230.

Currò S., De Marchi M., Claps S., Salzano A., De Palo P., Manuelian C.L., Neglia G. Differences in the Detailed Milk Mineral Composition of Italian Local and Saanen Goat Breeds. Animals (Basel). 2019;9:412.

Stergiadis S., Bieber A., Chatzidimitriou E., Fran­ceschin E., Isensee A., Rempelos, Baranski M., Maurer V., Cozzi G., Bapst B. et al. Impact of US Brown Swiss genetics on milk quality from low-input herds in Switzerland: Interactions with season. Food Chem. 2018;251:93–102.

Lythgoe H.C. Composition of goat milk of known purity. J. Dairy Sci. 1940;23:1097–1108.

Технический регламент Таможенного Союза «О безопасности молока и молочной продукции» (ТР ТС 033/2013)

Решение Совета ЕЭК от 23.09.2022 № 143 “О внесении изменений в технический регламент Таможенного союза “О безопасности молока и молочной продукции” (ТР ТС 033/2013)”.

Опубликован
2024-10-08
Как цитировать
Богданова, Н. М. (2024). УНИКАЛЬНОСТЬ СОСТАВА КОЗЬЕГО МОЛОКА И ПРЕИМУЩЕСТВА ИСПОЛЬЗОВАНИЯ ФОРМУЛ НА ЕГО ОСНОВЕ У МЛАДЕНЦЕВ, ЛИШЕННЫХ ГРУДНОГО МОЛОКА. Детская медицина Северо-Запада, 12(2), 74-88. https://doi.org/10.56871/CmN-W.2024.65.60.006
Раздел
Статьи