Chronic kidney disease and secondary hyperparathyroidism: causes and results relationships

Abstract

Based on the literature data, the problem of secondary hyperparathyroidism in patients with chronic kidney disease is considered. We discuss the role of changes in calcitriol secretion, its effect on the levels of ionized calcium and phosphorus, as well as processes of dysfunction of calcium and calcitriol receptors, the importance of early markers of chronic kidney disease - Klotho protein and fibroblast growth factor. The mechanisms of interaction between parathyroid hormone and parathyroid hormone related peptides with receptor cells, the role of secondary messengers are considered. The influence of these mechanisms on the clinical manifestations of the disease is discussed.