Expansion of the thoracic aorta and the activity of transforming growth factor-β in patients with marfanoid habitus

  • Евгений Владимирович Тимофеев Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
  • Эдуард Геннадьевич Малев Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
  • Нина Николаевна Парфенова Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
  • Светлана Вениаминовна Реева Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
  • Эдуард Вениаминович Земцовский Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Keywords: expansion of the aorta, marfanoid habitus, bone signs, transforming growth factor

Abstract

This article presents data on features of the thoracic aorta in patients with marfanoid habitus (MH) in various age groups. In patients of young age detected relatively larger diameter of aortic root, 25% of older patients with MH taped meaningful expansion of the aorta (Z-criterion > 2.0). As a pathogenetic basics remodeling of aorta in MH proven signaling pathway activation influence transforming growth factor-β - 45% of patients with MH exceeded the threshold of this cytokine.

Author Biographies

Евгений Владимирович Тимофеев, Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Litovskaya str., 2; Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases St. Petersburg State Pediatric Medical University
Эдуард Геннадьевич Малев, Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Litovskaya str., 2
Нина Николаевна Парфенова, Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Litovskaya str., 2
Светлана Вениаминовна Реева, Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Litovskaya str., 2
Эдуард Вениаминович Земцовский, Saint-Petersburg State Pediatric Medical University 194100, Saint-Рetersburg
Litovskaya str., 2
Published
2020-06-02
How to Cite
Тимофеев, Е. В., Малев, Э. Г., Парфенова, Н. Н., Реева, С. В., & Земцовский, Э. В. (2020). Expansion of the thoracic aorta and the activity of transforming growth factor-β in patients with marfanoid habitus. Medicine: Theory and Practice, 4(3), 142-147. Retrieved from https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/2318
Issue
Vol 4 No 3 (2019)
Section
Статьи