Humoral immune response in children with atopic dermatitis
Abstract
Comorbidity with allergic diseases is an important and common problem today. Especially often allergic diseases combined with gastroenterology diseases, endocrine disorders, dysfunction of the immune system. Disorders of the immune system with allergopathology is manifested by a decrease in the resistance of children to bacterial, viral, fungal, parasitic load. In the history of patients with severe allergopathology observed frequent exacerbation of the infectious process. The imbalance of the cellular immune response primarily leads to changes in the humoral immune response, which can be a predictor of the development of immunodeficiency and/or autoimmune pathology. The aim of the study is to study the features of humoral immune response in atopic dermatitis in children of early, preschool and school age. 130 children suffering from atopic dermatitis were examined. 1 group - children aged 3 months to 1 year (39 people), 2 group - children aged 2 to 6 years (25 people), 3 group - children aged 7 to 16 years (66 people). The levels of total IgA, IgM, IgG, IgE(radial immunodiffusion, ELISA), specific IgE (ELISA), circulating immune complexes, autoimmune antibodies (ELISA) were studied.
