GLUTEN INTOLERANCE MARKERS IN CHILDREN WITH AUTISM

Abstract

To date, a comprehensive medical approach in the treatment of autism spectrum disorders is preferred. In the process of treatment, psychiatrists, neurologists, psychologists, pediatricians, nutritionists and children's gastroenterologists should take part. This approach will optimize the treatment process and social rehabilitation, in particular, will allow an objective and individual approach to the appointment of a gluten free diet for children with autism. The question of including dietotarpia in the treatment process remains controversial; laboratory and clinical examination of a child with autism is necessary before excluding gluten from the diet. Purpose of the study. Assess the prevalence of gluten intolerance markers in children with autism spectrum disorders. Materials and methods. The sample consisted of 55 children aged 3 to 15 years with a previously diagnosed autism spectrum disorder. Of these, 20 children adhered to a gluten free diet for at least 6 months, while there was an improvement in health status. The enzyme linked immunosorbent assay was used to determine total IgA, antibodies to gliadin (IgG), antibodies to deamidated peptides of gliadin (IgA), and a genetic study was carried out by polymerase chain reaction. Statistical analysis was performed using statistical programs Statistica 6.0. Results. In children with autism spectrum disorders not committed to observing BHD, an increase in the level of antibodies to gliadin (IgG) was diagnosed in 17,1% of patients, and the values of antibodies to deamidated peptides of gliadin (IgA) are within the reference interval for all examined patients. Immunoglobulin A deficiency is detected in 9.1% of children with autism. 40-50% of examined patients with ASD were diagnosed with non celiac non allergic gluten sensitivity. Markers of a genetic predisposition to celiac disease (haplotypes of the HLA system DQ2 / DQ8) were diagnosed in 38.2% of children with ASD. Recommendations When diagnosing an autism spectrum disorder, it is advisable to conduct a survey to clarify the presence and nature of gluten intolerance for the timely selection of the optimal tactics of complex therapy.