Bone metabolism in young female ex athletes with hyperandrogenism associated with polycystic ovary syndrome

Abstract

The article discusses the features of bone and muscle tissue metabolism in former female athletes with polycystic ovary syndrome, and shows the relationship of ovarian hyperandrogenism with changes in bone tissue. Much attention is paid to the role of androgens in a woman’s body during high performance sports, and their influence on the sportive result. The mechanisms of the influence of androgens on mineral metabolism, carbohydrate metabolism, and the relationship with insulin resistance are considered in detail. The increased level of androgens in female athletes is a factor of rational adaptation, and the shutdown of sexual cycles with its help is a favorable protection of the reproductive system from damage. In particular, increasing the level of ovarian androgens helps prevent the development of bone deficiency and the development of osteopenia and osteoporosis. The appointment of androgen therapy contributes to the leveling of negative metabolic effects, but leads to the demineralization of bone tissue, the development of osteopenia and osteoporosis. Also, the appointment of androgen therapy contributes to a decrease in athletic performance in female athletes.