THE EFFECT OF LIPID PEROXIDATION PROCESS INITIATION ON THE PARAMETERS OF INTRACELLULAR GLUCOSE METABOLISM IN THE PATIENTS SUFFERING FROM DIABETES MELLITUS

Abstract

The effects of lipid peroxidation (LP) stimulants and single reinfusion of photomodified autoblood (PMB) on the laboratory parameters of free radical oxidation (FRO), key enzyme activity of glycolysis and pentose cycle in erythrocytes, blood serum glucose level in the patients suffering from diabetes mellitus (DM) are studied. It has been shown that the physiological effect of PMB is determined by LP stimulation changing the properties of the cell membranes, and the effect nature depends on the initial condition of LP processes in the erythrocytes of the patients suffering from DM. It is possible to use PMB in the complex treatment of the patients suffering from DM of the 2nd type as a factor activating the intracellular metabolism processes and improving glucose utilization in the tissues. DM of the 1st type is a relative contraindication for using PMB because the additional stimulation of LP processes may cause lowering of the activity of the intracellular enzyme systems involved in glucose metabolism.