Levels inflammatory cytokines (IL-8, TNFα) and anti-inflammatory interleukin (IL-4) in middle-aged men with acute coronary syndrome and stented coronary arteries

Abstract

It has now been established that inflammatory cytokines are involved in all the stages of the development of coronary heart disease. It has been scientifically proved that the severity of coronary heart disease directly correlates with the increase in the level of proinflammatory cytokines, while data on the role of proinflammatory interleukin IL-8 and anti inflammatory interleukin IL-4 are contradictory. The aim of the study is to evaluate the levels of proinflammatory cytokines (IL-8, TNFα) and anti inflammatory interleukin (IL-4) in patients with various forms of coronary heart disease who underwent stenting and re stenting of the coronary arteries. Materials and methods. By the method of enzyme linked immunosorbent assay, the levels of cytokines have been determined in 30 patients with acute coronary syndrome underwent primary stenting of the coronary arteries and in 28 patients who had previously undergone myocardial infarction with stenting of an infarct related artery, re admitted due to the development of acute coronary syndrome, who some time later underwent repeated stenting of coronary arteries. Results. The IL-4 level in patients with acute coronary syndrome with repeated stenting of coronary arteries and majority of patients with primary stenting of coronary arteries has been registered to be at a higher - 359,80±66,94 pg/ml and 240,85±49,25 pg/ml while р <0,08. The IL-8 level associated with patients with coronary arteries and majority of patients with primary stenting of coronary arteries has also been registered to be at high level - 69,75±18,25 pg/ml и 110,33±27,67 pg/ml while р >0,01. Conclusion. The increase in the level of IL-4 has a compensatory character and can be considered as a positive factor stabilizing the course of the disease.