Comparison of the morphological features of chronic esophagitis with the level of cytokines and neuropeptides in children with all ergic diseases

  • Анастасия Павловна Листопадова Saint-Petersburg State Pediatric Medical University; 8 th Children’s Polyclinic 194100, Russia, Saint-Рetersburg, Litovskaya str., 2; 191123, St. Petersburg, Tchaikovsky Str., 73
  • Валерия Павловна Новикова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Юлия Евгеньевна Замятина Saint-Petersburg State Pediatric Medical University; 8 th Children’s Polyclinic 194100, Russia, Saint-Рetersburg, Litovskaya str., 2; 191123, St. Petersburg, Tchaikovsky Str., 73
  • Елена Владимировна Невская North-Western State Medical University named after I.I. Mechnikov 195067, Russia, St. Petersburg, Piskarevsky Ave., 47
  • Ольга Петровна Гурина Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Ольга Николаевна Варламова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Александр Евгеньевич Блинов Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Эльвира Энгелевна Ашкрумова 8 th Children’s Polyclinic 191123, St. Petersburg, Tchaikovsky Str., 73
  • Ольга Юрьевна Паршуткина 8 th Children’s Polyclinic 191123, St. Petersburg, Tchaikovsky Str., 73
  • Олег Николаевич Нажиганов 8 th Children’s Polyclinic 191123, St. Petersburg, Tchaikovsky Str., 73
  • Ольга Павловна Листопадова Military Medical Academy. S.M. Kirov Russia 194044, St. Petersburg, ul. Academician Lebedev, 6
Keywords: esophagitis, eosinophilic neurotoxin, neuropeptide Y, substance P, cytokines (IL‑ 4, IL‑ 5 and IL‑ 13), atopic dermatitis, asthma, children

Abstract

to study the morphological features of chronic esophagitis in children with atopy (with atopic dermatitis, bronchial asthma) in comparison with cytokine status (IL‑ 4, IL‑ 5 and IL‑ 13), the level of markers of eosinophilic inflammation (eosinophilic cationic protein (ECP ) and eosinophilic neurotoxin (ED N)) and neuropeptides (neuropeptide Y (NPY ) and substance P (SP)). Patients and methods. The examined 61 children (mean age 13.9±2.36 years) having morphologically verified chronic esophagitis in the Сonsultative and diagnostic center with the day hospital of the 8 th Children's Polyclinic, St. P etersburg. The first group included 20 children with esophagitis and atopic dermatitis (AD ), the second group included 21 people with esophagitis in combination with atopic bronchial asthma (BA). The control group of 20 children with esophagitis without concomitant atopic diseases. The children underwent fibroesophagogastroduodenoscopy and sampling of mucosal biopsy material of the mucous membrane from the middle third of the esophagus. In all children, the level of total IgE was determined and a blood test for IL‑ 4, IL‑ 5 and IL‑ 13, ECP , ED N, NPY and SP was performed by ELI SA. Mathematical-statistical
data processing was carried out using the program Stat Soft Statistica 12.0. for Windows‑10. Research results. Morphological signs of esophagitis in the middle third of the esophagus equally often detected in the studied groups. The average level of total IgE in children with AD and esophagitis was 186.6±126.6 (N to 60) U /ml. The level of total IgE in the group of children with BA varied from 100 U/ml to 2000 U/ml, which, on average, was higher than normal and higher than with AD ; it was 331,5±238,6 U/ml. All children with esophagitis without atopic diseases had a level of total IgE within the normal range. In AD , IL‑ 4 levels (1.08±0.47 pg/ml and 1.91±0.88 pg/ml, p<0.05), IL‑ 5 (21.39±15.47 pg/ml and 1.91±0.88 pg/ml, p<0.05), IL‑ 13 (1.72±1.55 pg/ml and 12.11± 6.10 pg/ml, p<0.05), ED N (47.70±34.83 pg/ml and 119.00±64.26 pg/ml, p<0.05) and NPY (40.62±20.55 pg/ml and 160.44±144.44 pg/ml, p<0.005) were significantly lower than with the combination of esophagitis with BA and had no differences with the group of children without atopy. Conclusion. Esophagitis in children with bronchial asthma is accompanied by higher levels of IgE and more pronounced changes in cytokine status than in atopic dermatitis. The relationship between morphological and immunological parameters in patients with atopy was revealed. 

Published
2020-04-30
How to Cite
Листопадова, А. П., Новикова, В. П., Замятина, Ю. Е., Невская, Е. В., Гурина, О. П., Варламова, О. Н., Блинов, А. Е., Ашкрумова, Э. Э., Паршуткина, О. Ю., Нажиганов, О. Н., & Листопадова, О. П. (2020). Comparison of the morphological features of chronic esophagitis with the level of cytokines and neuropeptides in children with all ergic diseases. Medicine: Theory and Practice, 4(1), 164-171. Retrieved from https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/461
Issue
Vol 4 No 1 (2019)
Section
Статьи