The diagnostic significance of subpopulation composition of lymphocytes in atopic dermatitis in children of early age

  • Елена Александровна Дементьева Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Ольга Петровна Гурина Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Александр Евгеньевич Блинов Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Ольга Николаевна Варламова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Георгий Александрович Блинов Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Арина Александровна Степанова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
Keywords: lymphocyte subpopulations, atopic dermatitis, immune response

Abstract

The development of atopic dermatitis in young children is due to genetic predisposition,
diseases of the mother during pregnancy, as well as the impact of adverse environmental factors.
At the heart of the pathological process of hypersensitivity is the formation of an imbalance
between subpopulations of lymphocytes. 39 children aged from 3 months to 1 year were examined. Immunophenotyping of lymphocytes was carried out by the method of flow cytofluorometry using a non-washing technology. For the differentiation of lymphocytes in atopic dermatitis in young children is characterized by the presence of distinctive features in each of the age groups. Timely diagnosis of subpopulation composition of lymphocytes will allow pathogenetically justified immunocorrection to reduce the risk of concomitant pathology, as well as improve the effectiveness of basic therapy. 

Published
2020-04-30
How to Cite
Дементьева, Е. А., Гурина, О. П., Блинов, А. Е., Варламова, О. Н., Блинов, Г. А., & Степанова, А. А. (2020). The diagnostic significance of subpopulation composition of lymphocytes in atopic dermatitis in children of early age. Medicine: Theory and Practice, 4(1), 172-177. Retrieved from https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/462
Issue
Vol 4 No 1 (2019)
Section
Статьи