Influence of enterosorption on cytokine status during gastroduct and the related atopic diseases in children

  • Валерия Павловна Новикова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Анастасия Павловна Листопадова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Юлия Евгеньевна Замятина Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Юлия Сергеевна Карпеева Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Ольга Петровна Гурина Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Ольга Николаевна Варламова Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
  • Александр Евгеньевич Блинов Saint-Petersburg State Pediatric Medical University 194100, Russia, Saint-Рetersburg, Litovskaya str., 2
Keywords: chronic gastroduodenitis, atopic dermatitis, bronchial asthma, enterosorption, interleukin 4, interleukin 5 and eosinophilic neurotoxin

Abstract

Objective: to demonstrate the effectiveness of the sorbent “Zosterin-ultra‑60” in the treatment of children with chronic gastroduodenitis and concomitant atopic dermatitis and to study the cytokine mechanisms of its effect in comorbid pathology of the gastroduodenal zone and atopy. 41 children of school age (13.9±2.36 years) with morphologically verified chronic gastroduodenitis were examined. 20 of them suffered from concomitant atopic dermatitis in the acute stage, 21 people had chronic gastroduodenitis in combination with bronchial asthma (BA) of moderate severity. All patients with bronchial asthma and atopic dermatitis in therapy as an enterosorbent (enterosorbents included in the standard of treatment of ATD ) was prescribed Zosterin ultra 60%, a course for 10 days. Intake of the sorbent “Zosterin-ultra‑60” in asthma is accompanied by a decrease in levels of interleukin 4, interleukin 5 and eosinophilic neurotoxin. At atopic dermatitis — decreases the level of interleukin 4 in the blood. These cytokines, especially can be used as a marker of control therapy.

Published
2020-04-30
How to Cite
Новикова, В. П., Листопадова, А. П., Замятина, Ю. Е., Карпеева, Ю. С., Гурина, О. П., Варламова, О. Н., & Блинов, А. Е. (2020). Influence of enterosorption on cytokine status during gastroduct and the related atopic diseases in children. Medicine: Theory and Practice, 4(1), 195-204. Retrieved from https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/466
Issue
Vol 4 No 1 (2019)
Section
Статьи