Us e of a customized hypoall ergenic diet in treatment of patients with the inflamm atory bowel diseases

Abstract

Within 4 years, we observed and comprehensively examined 60 patients UC who received standard treatment. In group 1 (n=30) was used as a dietary therapy specific individual elimination hypoallergenic diet (ISEH diet), picked up in vitro and composed by exclusion from the diet of those products, which can be a source of food sensitization. To identify the immunopathological reactions I, III and IY types of food allergens used a range of methods — ELI SA (IgE‑ specific) and the reaction of inhibition migration of leukocytes(RIML ), modified by NN Matyshevа and LS Kositskаyа. Group 2 (n = 30) received a standard mechanically and chemically sparing diet. Patients with UC showed a high degree of sensitization to food antigens. Usage of the ISEН diet promoted a more rapid onset and prolonged maintenance of clinical and endoscopic remission, more than in the standard diet group, without the use of corticosteroids and thiopurins, as well as a significant decrease in the number of disease relapses. Diet of patients with UC should be hypoallergenic. The best results are observed in the preparation of a diet based on a comprehensive individual screening-testing of food allergens using laboratory diagnostic methods based on cell-type reactions and methods for detecting specific antibodies to food antigens. Results of a 4- year follow-up for patients with UC show high efficacy ISEH diet in the treatment and maintaining remission of these patients.