Ecopoll utants and asthma in children in metropolis

Abstract

BA is a sensitive marker of air pollution in large cities. The purpose is to study the characteristics of BA in children depending on the area of residence. 114 children with moderate asthma were examined. The average age of children was 5.33 ± 0.27 years. Group 1 — children in environmentally disadvantaged areas of the city of St. P etersburg, Group 2 — children living in environmentally safe areas of the city of St. P etersburg (according to the Committee for Environmental Management, Environmental Protection and Ensuring the Environmental Safety of St. Petersburg for the period 2013–2016 yy.) Mathematical-statistical
data processing was carried out using the program Stat Soft Statistica 6.0. and Microsoft Excel 7.0 for Windows XP. Most of the examined children suffering from AD live in areas with ecologically unfavorable state of atmospheric air (75% and 25%, p<0.05). The debut of the disease in patients from group 1 was observed at an earlier age (15±1.3 months). And 24±1,2 months. p<0.05), and the number of broncho-obstructive syndromes suffered by the child before the diagnosis of BA was significantly higher (9.1±0.3 and 5.2±0.2 p<0.05). In group 1 children, the degree of sensitization to the main allergens was significantly higher than in group 2 patients. In children of group 1 phagocytic number significantly exceeded those in patients
from group 2 (56.89±4.38 and 29.67±5.82, p<0.05), with reduced rates of phagocytic index and completion of phagocytosis. Conclusion. children with AD , living in ecologically unfavorable areas of the metropolis, characterized by an earlier onset of the disease, a high level of total IgE, expressed polyvalent sensitization; patients, living in ecologically unfavorable areas of the metropolis, there is a change in the indicators of innate immunity.