PATHOPHYSIOLOGICAL ASPECTS OF THE FORMATION OF INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

  • Анна Николаевна Тайц Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
  • Ирина Николаевна Воробцова Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
  • Людмила Витальевна Курдынко Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
  • Виктор Владимирович Смирнов Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
  • Анна Борисовна Шаповалова Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
  • Грета Кахаберовна Церцвадзе Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
Keywords: polycystic ovary syndrome, oxidative stress, hyperandrogenism, insulin resistance

Abstract

The article presents the results of literature data analysis about the main developing mechanisms of insulin resistance in women with PCOS (polycystic ovary syndrome). According to various scientific studies, the prevalence of PCOS is 53% among women with endocrine pathology. Due to contemporal data, PCOS is considered in the context of endocrine pathologies as a complex of hyperandrogenism, obesity, insulin resistance, disturbance of the regularity of the menstrual cycle, infertility. Many factors are associated with the formation of insulin resistance in women with PCOS. The main factors are: “mitochondrial dysfunction” and its relation to oxidative stress which contributes to the formation of insulin resistance and metabolic disorders in mitochondria. The influence of hyperandrogenism on carbohydrate and adipose metabolism and the relation of hyperandrogenia and hyperinsulinemia are discussed.

Author Biography

Анна Николаевна Тайц, Saint-Petersburg State Pediatric Medical University 194100, Saint-Petersburg, Litovskaya str., 2
Contact Information: Anna N. Taits - PhD, associate Professor of obstetrics and gynecology with the course of gynecology of childhood, head of the Department of gynecology of the Perinatal center, head of the Department of gynecology in the Perinatal Center Saint-Petersburg State Pediatric Medical University.
Published
2020-05-12
How to Cite
Тайц, А. Н., Воробцова, И. Н., Курдынко, Л. В., Смирнов, В. В., Шаповалова, А. Б., & Церцвадзе, Г. К. (2020). PATHOPHYSIOLOGICAL ASPECTS OF THE FORMATION OF INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME. Medicine: Theory and Practice, 3(2), 19-25. Retrieved from https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/492
Issue
Vol 3 No 2 (2018)
Section
Статьи