Polymorphism of renin angiotenzyn system genes in chronic diseases of kidney associated with congenital urinary deviation diseases

Abstract

The aim of our study was a comparative assessment of genetic predisposition to malignant course of chronic kidney disease (CKD) in children with congenital urinary tract abnormalities (CAKUT) and nephritis based on the study of gene polymorphism of the renin-angiotensin system. Methods. This was a prospective, observational, controlled, single-center study. The development includes 95 children. Patients, depending on the cause of CKD, were divided into two groups - comparison group (n=52), children with glomerulonephritis. The study group (n=43) included patients who had CPB development associated with CAKUT. a definition of the frequencies of alleles and genotypes of polymorphic loci of renin-angiotenzinovyh system (angiotensin-converting enzyme (ACE, (Ins-Del)), angiotenzinoguena (AGT, rs4762 (Thr174Met), rs699 (M235T). Results. In children with CKD is not detected due to the CAKUT of assotsiirovannye with gene variants responsible for the progression of CKD. Children with CKD associated with glomerulonephritis have a significantly high incidence of allele with the AGT gene. Any genetic predisposition to arterial hypertension in the studied children was not revealed. Conclusion. In children with CAKUT, the risk of progression of CKD is not associated with genetic predisposition factors in the genes of the renin-angiotensin system.