ACUTE CORONARY SYNDROME, CYTOKINE PROFILE AND MARKERS OF ENDOTHELIAL DYSFUNCTION IN MIDDLE-AGED MEN

Abstract

It has now been established that inflammatory cytokines are involved in all stages of the development of coronary heart disease. Endothelial dysfunction also plays a separate role in atherogenesis, and in patients with vitamin D deficiency in the body, the risk of developing vascular accidents is much higher than in healthy patients. The levels of cytokines, endothelin-1, VEGF-A, homocysteine and vitamin D were determined in 45 patients aged 45 to 59 years with acute coronary syndrome. The mean age of the patients was 55.9 ± 3.7 years. Patients aged 55-59 years (73.3 %) prevailed. Compared with the data of the control group, patients with acute coronary syndrome have an increase in the levels of IL-4 and IL-8 (244,0 ± 29,7 and 109,3 ± 16,4 pg/ml), at p < 0.05 and endothelin-1 (6.51 ± 1.2 pg/ml), at p < 0.05, while vitamin D values are below the reference values (21.88 ± 2.2 ng/ml), at p < 0.05.