THE PREVALENCE OF EXTERNAL AND CARDIAC SIGNS OF DYSEMBRIOGENESIS AT THE APPARENTLY HEALTHY YOUNG PEOPLE

Abstract

One of the most common and studied pathology phenotypes is marfanoid habitus, a diagnostic algorithm which relies on identifying signs of bone of dysembriogenesis. Questions the prevalence of bone signs and their relationship with skin and cardiac signs had not previously been studied. Objective: to examine the prevalence of external and cardiac signs of dysembriogenesis and select the most specific ones. Materials and methods: twenty 967 practically healthy young adults aged 18 to 25 years old (330 boys and 637 girls), 611 of which study Echocardiography was performed deliberately finding small abnormalities of the heart. The results. External and cardiac signs of dysembriogenesis among young people are fairly widespread. Among males more frequently detected bone symptoms such as chest deformity high sky and arachnodactyly. Among females more often identifies the hypermobility of joints and skin scars. Identified correlations between bone characteristics, such as arachnodactyly, dolyhostenomelia, high sky with skin signs and small anomalies of heart. It is shown that the use of the diagnostic threshold and 3 small heart anomalies leads to gyperdiagnosis the syndrome of the connective tissue of the heart. Conclusion: the prevalence of gender differences identified external signs of dysembriogenesis and small anomalies of heart should be taken into account in the development of algorithms for diagnosis of marfanoid habitus. Among bone signs most specific should be considered arachnodactyly, dolyhostenomelia, high sky, deformities of the chest.